Mode of action of lindane, dieldrin and related insecticides in the central nervous system.
Mode of action of lindane, dieldrin and related insecticides in the central nervous system.
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林丹、狄氏剂和相关杀虫剂在中枢神经系统中的作用方式。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
R. Joy
中科院分区：
文献类型：
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作者：
R. Joy
提出了林丹、狄氏剂和相关氯化烃杀虫剂的作用模式。现有的证据表明，这些杀虫剂以全局方式作用于神经元。它们的主要靶点是突触，主要通过增强突触前末梢的递质释放来增强突触活动。所有神经元似乎都受到影响。在神经系统中没有明显的兴奋或抑制系统偏好，也没有证据表明对单一神经递质或神经递质系统有特定作用。有人提出，行为中发生的变化是基于这种相同的作用模式。一个简化的大脑可塑性模型，点燃癫痫发作模型，被描述为一个潜在的工具，为进一步调查。
A mode of action for lindane, dieldrin and related chlorinated hydrocarbon insecticides is proposed. The available evidence suggests that these insecticides act upon neurons in a global manner. Their primary target is the synapse, and they act there to intensify synaptic activity, primarily by enhancing transmitter release from the presynaptic terminal. All neurons appear to be affected. There is no apparent predilection for excitatory or inhibitory systems in the nervous system nor is there evidence for a specific action upon a single neurotransmitter or neurotransmitter system. It is proposed that the modifications that occur in behavior are based upon this same mode of action. A simplified model of brain plasticity, the kindled seizure model, is described as a potential tool for further investigation.