Immunometabolic Signaling Pathways Contribute to Macrophage and Dendritic Cell Function.
Immunometabolic Signaling Pathways Contribute to Macrophage and Dendritic Cell Function.
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DOI：
10.1615/critrevimmunol.2017018803
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发表时间：
2016
影响因子：
1.3
通讯作者：
Hahn YS
中科院分区：
文献类型：
--
作者：
Jennelle LT;Dandekar AP;Magoro T;Hahn YS
通过大量使用系统生物学方法的研究，对抗原呈递细胞（APC）参与组织炎症和代谢的理解已经取得了进展。以前未被认识到的这些研究领域之间的联系已经阐明了炎症性疾病涉及先天性和适应性免疫反应的背景下。一个新的概念框架桥梁APC生物学，代谢和细胞因子在产生有效的T细胞反应。探索这些联系对于解决多器官系统疾病的上升趋势至关重要，特别是与代谢综合征，感染和癌症相关的慢性疾病。这些领域的重点研究将有助于开发利用和操纵先天免疫学的策略，以改善疫苗开发，抗病毒，抗炎和抗肿瘤治疗。这篇综述强调了APC“免疫代谢”的最新进展，特别是与人类慢性病毒和代谢性疾病。本次审查的目标是开发一个简短的和巩固的前景，最近的主题更新APC免疫代谢的调节和代谢和炎症信号之间的串扰和综合应激反应，以及这些信号如何决定APC的功能，在提供T细胞活化信号3。
Understanding of antigen-presenting cell (APC) participation in tissue inflammation and metabolism has advanced through numerous studies using systems biology approaches. Previously unrecognized connections between these research areas have been elucidated in the context of inflammatory disease involving innate and adaptive immune responses. A new conceptual framework bridges APC biology, metabolism, and cytokines in the generation of effective T-cell responses. Exploring these connections is paramount to addressing the rising tide of multi-organ system diseases, particularly chronic diseases associated with metabolic syndrome, infection, and cancer. Focused research in these areas will aid the development of strategies to harness and manipulate innate immunology to improve vaccine development, anti-viral, anti-inflammatory, and anti-tumor therapies. This review highlights recent advances in APC “immunometabolism” specifically related to chronic viral and metabolic disease in humans. The goal of this review is to develop an abridged and consolidated outlook on recent thematic updates to APC immunometabolism in the areas of regulation and crosstalk between metabolic and inflammatory signaling and the integrated stress response and how these signals dictate APC function in providing T-cell activation Signal 3.