MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways.
MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways.
复制标题
MicroRNA-145癌症和心血管系统的靶标：常见信号通路的证据。
DOI：
10.1530/vb-20-0012
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Lilly B
中科院分区：
文献类型：
--
作者：
Sawant D;Lilly B
MiRNAs是一种小分子调控RNA，主要与靶基因的3‘-UTR区结合，在转录后调控基因表达。MIR-145是一种研究得很好的miRNA，参与了一系列生物过程的控制。MIR-145在多种组织和细胞类型中表达，通过调节参与肿瘤生长和进展的不同方面的靶基因信号通路而发挥肿瘤抑制作用。也有强有力的证据表明miR-145在心血管系统中的重要作用。在这里，我们综述miR-145在肿瘤发生和癌症进展中的作用机制，并与miR-145在心血管发育和疾病中的作用进行比较和对比。我们讨论了miR-145在癌症中的重要靶点及其与心血管系统的可能联系。
miRNAs are small regulatory RNAs which govern gene expression post-transcriptionally by primarily binding to the 3'-UTR of mRNA target genes. miR-145 is a well-studied miRNA that has been implicated in controlling a range of biological processes. miR-145 is expressed in a variety of tissues and cell types and acts as a tumor-suppressor by regulating target gene signaling pathways involved in different aspects of tumor growth and progression. There is also strong evidence that highlights the important functions of miR-145 in the cardiovascular system. Here, we review the mechanisms of miR-145 in tumorigenesis and cancer progression and compare and contrast with the roles of miR-145 in cardiovascular development and disease. We discuss the important targets of miR-145 in cancer and their possible link to the cardiovascular system.