Asymmetric Synthesis of Rugulotrosin A
Asymmetric Synthesis of Rugulotrosin A
复制标题
鲁古洛辛 A 的不对称合成
DOI：
10.1021/acs.orglett.0c00063
复制
发表时间：
2020-02-21
期刊：
影响因子：
5.2
通讯作者：
Gao, Shuanhu
中科院分区：
文献类型：
--
作者：
Chen, Jianhua;Li, Yayue;Gao, Shuanhu
以易得的1，3-环己二酮和不饱和醛为原料，通过Knoevenagel缩合/6 π电子环化/芳构化级联反应合成四羟基蒽酮.这一策略为制备12位带有不同官能团的单体四氧杂蒽酮提供了一种新的方法。作为合成应用，实现了rugulotrosin A的不对称形式合成。
A new approach was developed to construct the tetrahydroxanthone by a Knoevenagel condensation/6 pi-electronic cyclization/aromatization cascade starting from readily available cyclohexane-1,3-diones and unsaturated aldehydes. This strategy provides a new solution for the preparation of monomeric tetrahydroxanthones bearing different functional groups at C-12. As a synthetic application, the asymmetric formal synthesis of rugulotrosin A was achieved.