Effects of Peripheral μ, δ, and κ-Opioid Receptor Agonists on the Levels of Anxiety and Motor Activity of Rats
Effects of Peripheral μ, δ, and κ-Opioid Receptor Agonists on the Levels of Anxiety and Motor Activity of Rats
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DOI：
10.1007/s10517-012-1809-2
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发表时间：
2012-09-01
影响因子：
0.7
通讯作者：
Sudakov, S. K.
中科院分区：
文献类型：
--
作者：
Alexeeva, E. V.;Nazarova, G. A.;Sudakov, S. K.
本实验观察了阿片受体激动剂DAMGO、DADLE和ICI204、448分别灌胃给药对大鼠在高架正迷宫中焦虑和运动活动的影响。外周给予ICI204,448可产生抗焦虑作用，但对大鼠的运动活动无影响。DAMGO和DADLE减少了运动活动；DADLE也增加了焦虑。ICI 204,448和DADLE对焦虑的相反作用的数据证实了我们之前关于内源性阿片系统的中枢和外周成分之间相互作用的假设。
The effects of intragastric administration of mu-, delta, and kappa-opioid receptor agonists DAMGO, DADLE, and ICI 204,448, respectively, on the anxiety and motor activity of rats in an elevated plus-maze were studied. Peripheral administration of ICI 204,448 produced an anxiolytic effect, but had no effect on motor activity of rats. DAMGO and DADLE reduced motor activity; DADLE also increased anxiety. The data on the opposite effects of ICI 204,448 and DADLE on anxiety confi rmed our previous hypothesis on the interactions between the central and peripheral components of the endogenous opioid system.