Pulmonary thromboembolism superimposed on a congenital ventricular septal defect in a 50-year-old man inhaled nitric oxide and sildenafil to the rescue.
Pulmonary thromboembolism superimposed on a congenital ventricular septal defect in a 50-year-old man inhaled nitric oxide and sildenafil to the rescue.
复制标题
一名 50 岁男性先天性室间隔缺损合并肺血栓栓塞，吸入一氧化氮和西地那非进行抢救。
DOI：
10.1097/01.crd.0000122635.12743.57
复制
发表时间：
2004
影响因子：
2.1
通讯作者：
Semigran,MarcJ
中科院分区：
文献类型：
--
作者：
Lewis,GregoryD;Bloch,KennethD;Semigran,MarcJ
We report the combined use of inhaled nitric oxide (iNO) and sildenafil to selectively lower pulmonary vascular resistance (PVR) and reverse right-to-left shunt flow across a congenital ventricular septal defect (VSD) in a 50-year-old man. The patient developed right-to-left shunt flow with profound hypoxia because of an acute pulmonary embolism superimposed on underlying pulmonary hypertension. The dramatic improvement in oxygenation and PVR with sildenafil plus iNO has been sustained with sildenafil monotherapy. To our knowledge, use of this combination therapy in patients with decompensated pulmonary arterial hypertension (PAH) and a predisposition to right-to-left shunting has not been previously reported.
