Maresins: anti-inflammatory pro-resolving mediators with therapeutic potential.
Maresins: anti-inflammatory pro-resolving mediators with therapeutic potential.
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DOI：
10.26355/eurrev_202007_21913
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发表时间：
2020-07
影响因子：
3.3
通讯作者：
Q-F Li;H. Hao;Wenjuan Tu;N. Guo;X-Y Zhou
中科院分区：
文献类型：
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作者：
Q-F Li;H. Hao;Wenjuan Tu;N. Guo;X-Y Zhou
Although inflammation is protective of the body, uncontrolled acute inflammatory reactions may inflict tissue damage and lead to chronic inflammation. There is a fast-growing research interest in mechanisms that mediate regression of inflammation and actions of anti-inflammatory factors. Studies of inflammatory and anti-inflammatory mechanisms have uncovered roles for new lipid mediators, including lipoxins, resolvins, protectins, and maresins, collectively referred to as specialized pro-resolving mediators (SPM). Maresins have recently been discovered and are biosynthesized from docosahexaenoic acid (DHA) by macrophages and display strong anti-inflammatory and pro-resolving activities. Here, we summarize the actions and mechanisms of maresins in different diseases and suggest possible therapeutic uses.
