RACK1 Function in Cell Motility and Protein Synthesis.
RACK1 Function in Cell Motility and Protein Synthesis.
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DOI：
10.1177/1947601913486348
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发表时间：
2013-09-01
期刊：
影响因子：
--
通讯作者：
Ronai, Ze'ev A
中科院分区：
文献类型：
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作者：
Gandin, Valentina;Senft, Daniela;Ronai, Ze'ev A
活化 C 激酶 1 (RACK1) 的受体充当 MAPK、蛋白激酶 C 和 Src 信号通路上许多蛋白质的接头。 RACK1 的丰富性和几乎无处不在的表达反映了它在协调许多关键生物过程的信号分子中的作用，从 mRNA 翻译到细胞运动，再到细胞生存和死亡。 Rack1 完全缺乏会导致胚胎死亡，但最近开发的 Rack1 基因亚型小鼠强调了 RACK1 在细胞运动和蛋白质合成中发挥的核心作用。本综述重点关注 RACK1 在这些过程中的重要性，并将最近的工作放在理解 RACK1 功能的更大背景下。
The receptor for activated C kinase 1 (RACK1) serves as an adaptor for a number of proteins along the MAPK, protein kinase C, and Src signaling pathways. The abundance and near ubiquitous expression of RACK1 reflect its role in coordinating signaling molecules for many critical biological processes, from mRNA translation to cell motility to cell survival and death. Complete deficiency of Rack1 is embryonic lethal, but the recent development of genetic Rack1 hypomorphic mice has highlighted the central role that RACK1 plays in cell movement and protein synthesis. This review focuses on the importance of RACK1 in these processes and places the recent work in the larger context of understanding RACK1 function.