Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells
Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells
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DOI：
10.1016/j.bmc.2005.08.005
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发表时间：
2006-01-01
影响因子：
3.5
通讯作者：
Asakawa, Y
中科院分区：
文献类型：
--
作者：
Quang, DN;Hashimoto, T;Asakawa, Y
从食用菌Albatrellus caeruleoporus的甲醇提取物中分离得到两个新的法尼基酚，分别命名为grifolinones A和B，以及已知的grifolin和neogrifolin。其结构经2D NMR、MS、IR和UV光谱表征。Grifolinone B由两个Grifolin分子通过C-C键连接而成。Grifolinone A和B、Grifolin和neogrifolin对RAW 264.7细胞中脂多糖（LPS）刺激的一氧化氮（NO）产生具有抑制活性，IC 50值分别为23.4、22.9、29.0和23.3 μ M。(c)2005爱思唯尔有限公司保留所有权利。
Two new farnesyl phenols named grifolinones A and B, together with known grifolin and neogrifolin, were isolated from methanolic extract of the inedible mushroom Albatrellus caeruleoporus. Their structures were characterized by a combination of 2D NMR, MS, IR, and UV spectra. Grifolinone B was composed of two grifolin Molecules, which were connected by a C-C bond. Grifolinones A and B, grifolin, and neogrifolin exhibited inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with IC50 values of 23.4, 22.9, 29.0, and 23.3 mu M, respectively. (c) 2005 Elsevier Ltd. All rights reserved.