Menstrual and reproductive factors for subarachnoid hemorrhage risk in women - A case-control study in Nagoya, Japan
Menstrual and reproductive factors for subarachnoid hemorrhage risk in women - A case-control study in Nagoya, Japan
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DOI：
10.1161/hs1201.099383
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发表时间：
2001-12-01
期刊：
影响因子：
8.3
通讯作者：
Ohno, Y
中科院分区：
文献类型：
--
作者：
Okamoto, K;Horisawa, R;Ohno, Y
背景和目的：采用病例对照研究方法，探讨月经因素和生殖因素与蛛网膜下腔出血发病风险的关系。方法连续收集经血管造影和(或)CT扫描证实的首发自发性蛛网膜下腔出血患者(S)124例。结果：SAH风险增加与(1)月经初潮年龄较早(13岁与13岁的调整优势比[OR]=3.24；95%可信区间，1.25~4.03)和(2)未发病相关(调整后的OR=4.23；95%可信区间，1.05~7.56)。未发现SAH风险与月经周期的规律性、怀孕时的年龄、第一次出生的年龄和出生数量显著相关。未月经和月经初潮早(13年)的风险最大(调整后OR=6.37；95%CI，1.12~36.2)。结论：与月经和生育史相关的多个变量联合作用对SAH风险的影响可能比单一月经或生殖因素更大。
Background and Purpose-We sought to examine the relationship between menstrual and reproductive factors and the risk of subarachnoid hemorrhage (SAH), using a case-control study.Methods-Cases consisted of a consecutive series of 124 women patients with first spontaneous SAH aged 30 to 79 years and confirmed aneurysm(s) by angiography and/or CT scan. Hospital and community controls subjects were identified, is matched to each case by age (+/- 2 years).Results-Increased SAH risk was associated with (1) earlier age at menarche (adjusted odds ratio [OR] = 3.24 for age < 13 years compared with age :13 years; 95% CI, 1.25 to 4.03) and (2) nulligravidity (adjusted OR = 4.23; 95% CI, 1.05 to 7.56). No significant association of SAH risk was found with regularity of menstrual cycle, age at pregnancy, age at first birth, and number of births. The greatest risk was for the combined effect of nulligravidity and earlier menarche (< 13 years) (adjusted OR = 6.37; 95% CI, 1.12 to 36.2).Conclusions-The combined effect of several variables related to menstrual and reproductive history may exert a greater influence on risk of SAH compared with a single menstrual or reproductive variable.