Delayed administration of basic fibroblast growth factor protects against N-methyl-D-aspartate neurotoxicity in neonatal rats.
Delayed administration of basic fibroblast growth factor protects against N-methyl-D-aspartate neurotoxicity in neonatal rats.
复制标题
延迟施用碱性成纤维细胞生长因子可防止新生大鼠遭受 N-甲基-D-天冬氨酸神经毒性。
DOI：
10.1016/0014-2999(93)90788-j
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发表时间：
1993
影响因子：
5
通讯作者：
Beal,MF
中科院分区：
文献类型：
--
作者：
Nozaki,K;Finklestein,SP;Beal,MF
碱性成纤维细胞生长因子（bFGF）（200 μ/kg i. p.）在7日龄大鼠纹状体内注射N-甲基-D-天冬氨酸（NMDA）后的不同时间点进行检测。当在纹状体内注射NMDA前0.5 h给药时，与溶剂处理相比，200 μ g/kg bFGF显著减少NMDA诱导的损伤47%。在注射NMDA后0、0.5或1 h用相同剂量的bFGF进行后处理，也分别使这些病变显著减少45、35或26%，而在注射NMDA后2或4 h给药时没有观察到神经保护作用。
Neuroprotective effects of basic fibroblast growth factor (bFGF) (200 μ/kg i.p.) were examined at different time points following intrastriatal injection of N-methyl-D-aspartate (NMDA) in seven-day-old rats. When administered 0.5 h before intrastriatal NMDA injection, 200 μ/kg of bFGF significantly reduced NMDA-induced lesion by 47% as compared with vehicle treatment. Posttreatment with the same dose of bFGF at 0, 0.5 or 1 h after NMDA injection also significantly reduced those lesions by 45, 35 or 26%, respectively, while no neuroprotective effects was observed when administered at 2 or 4 h after NMDA injection.