Inflammation of craniofacial muscle induces widespread mechanical allodynia
Inflammation of craniofacial muscle induces widespread mechanical allodynia
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DOI：
10.1016/j.neulet.2006.02.003
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发表时间：
2006-05-22
影响因子：
2.5
通讯作者：
Dessem, Dean
中科院分区：
文献类型：
--
作者：
Ambalavanar, Ranjinidevi;Moutanni, Aicha;Dessem, Dean
在大鼠中研究了在离散的躯体注射完全弗氏佐剂（CFA）后由局部和远处伤害性刺激诱发的行为反应的调制。一个颅面肌的炎症引起的机械异常性疼痛不仅在该地区的炎症，但也继发性机械异常性疼痛在对侧头部，同侧后爪，对侧后爪。与此相反，CFA诱导的后爪或腓肠肌炎症引起的机械性异常性疼痛仅限于后肢区域。这项研究中发现的深部颅面组织炎症引起的疼痛反应行为的广泛调制类似于纤维肌痛、挥鞭样损伤和一些颞下颌关节紊乱病中报道的广泛的深部组织疼痛，因此可以深入了解这些肌肉骨骼病理学的机制。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
The modulation of behavioral responses evoked by local and distant nociceptive stimuli following a discrete somatic injection of complete Freund's adjuvant (CFA) was examined in rats. Inflammation of one craniofacial muscle evoked mechanical allodynia not only in the region of inflammation but also secondary mechanical allodynia in the contralateral head, ipsilateral hindpaw, and contralateral hindpaw. In contrast to this, CFA-induced inflammation of either the hindpaw or gastrocnemius muscle evoked mechanical allodynia restricted to the hindlimb region. The widespread modulation of nocifensive behavior evoked by inflammation of deep craniofacial tissue found in this study resembles the widespread deep tissue pain reported in fibromyalgia, whiplash injury and some temporomandibular disorders and thus may provide insight into the mechanisms of these musculoskeletal pathologies. (c) 2006 Elsevier Ireland Ltd. All rights reserved.