Thunberginols A, B, and F, new antiallergic and antimicrobial principles from hydrangeae dulcis folium.
Thunberginols A, B, and F, new antiallergic and antimicrobial principles from hydrangeae dulcis folium.
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Thunberginols A、B 和 F，来自绣球花的新抗过敏和抗菌原理。
DOI：
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发表时间：
1992
影响因子：
1.7
通讯作者：
J. Yamahara
中科院分区：
文献类型：
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作者：
M. Yoshikawa;E. Uchida;N. Chatani;N. Murakami;J. Yamahara
从大叶绣球（Hydrangeae Dulcis Folium）的发酵和干燥叶中分离得到了6个新的抗过敏和抗菌成分，分别为大叶绣球（Hydrangeae Dulcis Folium）的大叶绣球酚A、B、C、D、E和F。根据化学和生理化学的证据确定了雷公酚A、B和F的化学结构。在致敏豚鼠支气管肌的体外舒尔-戴尔反应试验中，黄芪酚A、B和F比叶黄素、绣球烯醇和AA-861表现出更强的抗过敏活性。黄芩酚A、B和F对口腔细菌也表现出抗菌活性。
Six new antiallergic and antimicrobial principles, thunberginols A, B, C, D, E, and F, were isolated from Hydrangeae Dulcis Folium, the fermented and dried leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO. The chemical structures of thunberginols A, B, and F have been determined on the basis of chemical and physiocochemical evidence. Thunberginols A, B, and F showed more potent antiallergic activity than phyllodulcin, hydrangenol, and AA-861 in the in vitro test using the Schults-Dale reaction in sensitized guinea pig bronchial muscle. Thunberginols A, B, and F also exhibited antimicrobial activity against oral bacteria.