Relationship of Central Choroidal Thickness With Age-Related Macular Degeneration Status
Relationship of Central Choroidal Thickness With Age-Related Macular Degeneration Status
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DOI：
10.1016/j.ajo.2014.12.010
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发表时间：
2015-04-01
影响因子：
4.2
通讯作者：
Toth, Cynthia A.
中科院分区：
文献类型：
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作者：
Yiu, Glenn;Chiu, Stephanie J.;Toth, Cynthia A.
目的：使用增强深度成像光学相干断层扫描 (EDI-OCT) 比较中度或晚期年龄相关性黄斑变性 (AMD) 患者和对照受试者的脉络膜厚度。设计：对年龄相关眼病研究 (AREDS) 2 辅助谱域 OCT 研究中接受 EDI-OCT 的 164 名受试者的 325 只眼睛进行回顾性横断面研究。方法：通过以下方法测量脉络膜厚度：从中央凹鼻部 1.5 毫米到颞部 1.5 毫米的 EDI-OCT 图像半自动分割。使用多元线性回归来评估中心凹下脉络膜厚度或中央 3 毫米段的平均脉络膜厚度与全身和眼部变量的关联。对无 AMD (n = 154)（即对照）、中度 A/vfD (n = 109) 和晚期 AMD (n = 62) 的眼睛之间的脉络膜厚度测量结果进行比较。结果：中心凹下和平均脉络膜厚度均与年龄 (P < .001) 和屈光不正 (P < .001) 相关，但与测试的其他变量无关。与对照眼相比，晚期 AMD 的平均脉络膜厚度显着降低 (P = .008)，而晚期和中度 AMD 眼之间 (P = .152) 或中度 AMD 和对照眼之间 (P = .098) 之间没有显着差异。与对照眼相比，晚期 AIYID 也从鼻侧 1.5 毫米到颞侧 1.5 毫米变薄（在所有 0.5 毫米间隔位置处，P < .05），然而，在调整年龄和屈光不正后，所有 3 组的中心凹下 (P = .675) 或平均脉络膜厚度 (P = .746) 没有显着差异。根据 AREDS 分类，中央脉络膜厚度可能不会受到 AMD 状态的显着影响。 (C) 2015 年，Elsevier Inc. 保留所有权利。
PURPOSE: To compare choroidal thickness in patients with intermediate or advanced age-related macular degeneration (AMD) and control subjects using enhanced-depth imaging optical coherence tomography (EDI-OCT).DESIGN: Retrospective cross-sectional study of 325 eyes from 164 subjects who underwent EDI-OCT for the Age-Related Eye Disease Study (AREDS) 2 Ancillary Spectral Domain OCT study.METHODS: Choroidal thickness was measured by semiautomated segmentation of EDI-OCT images from 1.5 mm nasal to 1.5 mm temporal to the fovea. Multivariate linear regression was used to evaluate the association of subfoveal choroidal thickness or average choroidal thickness across the central 3-mm segment with systemic and ocular variables. Choroidal thickness measurements were compared between eyes with no AMD (n = 154) (ie, controls), intermediate A/vfD (n = 109), and advanced AMD (n = 62). "RESULTS: Both subfoveal and average chorciidal thicknesses were associated with age (P < .001) and refractive error (P < .001), but not other variables tested. Mean average choroidal thickness was significantly reduced in advanced AMD as compared with control eyes (P =.008), with no significant difference between advanced and intermediate AMD eyes (P = .152) or between intermediate AMD and control eyes (P = .098). Choroidal thinning was also noted from 1.5 mm nasal to 1.5 mm temporal to the fovea when comparing advanced AIYID with control eyes (P < .05 at all 0.5 mm interval locations). After adjustment for age and refractive error, however, there was no significant difference in subfoveal (P = .675) or average choroidal thickness (P = .746) across all 3 groups. "CONCLUSIONS: When adjusted for age and refractive error, central choroidal thickness may not be significantly influenced by AMD status based on AREDS categorization. (C) 2015 by Elsevier Inc. All rights reserved.