Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations
Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations
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DOI：
10.1126/science.abd3663
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发表时间：
2020-11-20
期刊：
影响因子：
56.9
通讯作者：
Lambrechts, Louis
中科院分区：
文献类型：
--
作者：
Aubry, Fabien;Dabo, Stephanie;Lambrechts, Louis
人畜共患病病毒在人群中出现的驱动因素和模式知之甚少。埃及伊蚊是一种主要的虫媒病毒，原产于非洲，在过去的四个世纪里入侵了世界上大部分的热带地区，在进化出一种专门叮咬人类和在储水容器中繁殖的“家养”形式之后。在这里，我们表明，人类的专业化和随后的传播A。埃及人从非洲迁出的同时，其获得和传播新出现的人类病原体寨卡病毒的内在能力也在增加。因此，最近的演变和全球扩张的A。埃及伊蚊不仅通过增加病媒与宿主的接触，而且还通过增强病媒的易感性，促进虫媒病毒的出现。
The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that invaded most of the world's tropical belt over the past four centuries, after the evolution of a "domestic" form that specialized in biting humans and breeding in water storage containers. Here, we show that human specialization and subsequent spread of A. aegypti out of Africa were accompanied by an increase in its intrinsic ability to acquire and transmit the emerging human pathogen Zika virus. Thus, the recent evolution and global expansion of A. aegypti promoted arbovirus emergence not solely through increased vector-host contact but also as a result of enhanced vector susceptibility.