Uterine and circulating natural killer cells and their roles in women with recurrent pregnancy loss, implantation failure and preeclampsia
Uterine and circulating natural killer cells and their roles in women with recurrent pregnancy loss, implantation failure and preeclampsia
复制标题
DOI：
10.1016/j.jri.2011.04.006
复制
发表时间：
2011-06-01
影响因子：
3.4
通讯作者：
Mizunuma, Hideki
中科院分区：
文献类型：
--
作者：
Fukui, Atsushi;Funamizu, Ayano;Mizunuma, Hideki
子宫和循环外周血自然杀伤（NK）细胞的调节与生殖条件有关，包括复发性妊娠丢失（RPL）、植入失败和先兆子痫。天然细胞毒性受体（NCRs）是调节NK细胞毒性和细胞因子产生的独特标记。ncr在生殖事件中的作用尚未得到充分的描述。未怀孕妇女外周血NK细胞中存在NK1（1型）移位，容易发生RPL和着床失败。子宫内膜或流产的蜕膜NK细胞中NCR表达的不同特征表明NK细胞在生殖失败女性中存在异常调节。有RPL病史和子痫前期的妇女在怀孕期间外周血NK细胞的NCRs免疫异常。评价NKp46对外周血NK细胞的影响可用于先兆子痫的预测。子痫前期妇女中NKp46(+) NK细胞的低表达可能是子痫前期孕妇中NK1细胞因子（即NK1移位）产生较高的原因。本文综述了外周血NK细胞和子宫内膜或蜕膜NK细胞中NCRs的表达与生殖失败的关系。2011爱思唯尔爱尔兰有限公司版权所有。
The regulation of uterine and circulating peripheral blood natural killer (NK) cells has been associated with reproductive conditions including recurrent pregnancy loss (RPL), implantation failure and preeclampsia. Natural cytotoxicity receptors (NCRs) are unique markers that regulate NK cell cytotoxicity and cytokine production. The role of NCRs in reproductive events has not yet been fully characterized. There is an NK1 (Type 1) shift in peripheral blood NK cells in non-pregnant women prone to RPL and implantation failure. The different profile of NCR expression in endometrial or aborted decidual NK cells suggests the presence of abnormal regulation of NK cells in women with reproductive failure. Women with a history of RPL and preeclampsia carry immunological abnormalities of NCRs on peripheral blood NK cells during pregnancy. Evaluation of NKp46 on peripheral blood NK cells may be applicable for the prediction of preeclampsia. The lower expression of NKp46(+) NK cells in women with preeclampsia may account for the higher production of NK1 cytokines - known as the NK1 shift - in pregnant women with preeclampsia. In this review, the expression of NCRs in peripheral blood NK cells and endometrial or decidual NK cells is discussed in relation to reproductive failure. (C) 2011 Elsevier Ireland Ltd. All rights reserved.