Baseline saliva level of 3-methoxy-4-hydroxyphenylglycole (MHPG) associates with a consequent cognitive decline in non-demented elderly subjects Three-years follow-up study
Baseline saliva level of 3-methoxy-4-hydroxyphenylglycole (MHPG) associates with a consequent cognitive decline in non-demented elderly subjects Three-years follow-up study
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3-甲氧基-4-羟基苯基乙二醇 (MHPG) 的基线唾液水平与非痴呆老年受试者随后的认知能力下降相关三年随访研究
DOI：
10.1016/j.psychres.2011.07.013
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发表时间：
2012
影响因子：
11.3
通讯作者：
S. Yamada
中科院分区：
文献类型：
--
作者：
Itaru Watanabe;Guang Y. Li;Yoshiomi Imamura;Hiromitsu Nabeta;Yutaka Kunitake;Hironobu Ishii;Masanori Haraguchi;Yuzo Furukawa;H. Tateishi;Naoki Kojima;Yoshito Nizoguchi;S. Yamada
本研究旨在探讨唾液中3-甲氧基-4-羟基苯乙二醇（MHPG）水平与非痴呆老年受试者后期认知功能下降之间的关系。本文报道了2004年至2006年（时间A）214例社区老年人（年龄74.5± 5.9岁）的sMHPG与简易精神状态检查（MMSE）和额面功能成套测验（FAB）的相关性。同一队列在2007年至2009年再次接受这些认知测试（时间B）。214名受试者中的147名的认知功能可以通过相同的认知测试重新评估。与时间A（15.2±1.9）相比，时间B（14.6±2.6）的FA B评分显著降低，但MMSE评分未降低。男性基线sMHPG与从时间B减去时间A的FA B评分变化或时间B的FA B评分之间存在显着负相关性，但与时间A的FA B评分之间不存在显着负相关性。在女性中没有发现这些相关性。这些数据表明，高sMHPG可能与随后的认知功能下降的FAB评估的非痴呆老年男性生活在社区。
The aim of the study was to explore the relation between saliva level of 3-methoxy-4-hydroxy-phenylglycol (MHPG) and a later cognitive decline in non-demented elderly subjects. We have reported that sMHPG in 214 elderly subjects living in the community (age 74.5±5.9years) was associated with scores on the Mini-Mental State Examination (MMSE) and the Frontal Assessment Battery (FAB) in 2004 to 2006 (Time A). The same cohort underwent these cognitive tests again from 2007 to 2009 (Time B). The cognitive function of the 147 of 214 subjects could be reassessed by the same cognitive tests. The score on the FAB, but not the MMSE, was significantly reduced at Time B (14.6±2.6) compared with that of Time A (15.2±1.9). There was a significant negative correlation between the baseline sMHPG and the changes in the FAB score subtracted from Time B to Time A or the scores on the FAB at Time B in men, but not at Time A. These correlations were not found in women. These data indicate that high sMHPG might be associated with subsequent cognitive decline assessed by the FAB in non-demented elderly men living in the community.
影响因子：
2.6
作者：
G. Y. Li;H. Ueki;Y. Yamamoto;S. Yamada
通讯作者：
G. Y. Li;H. Ueki;Y. Yamamoto;S. Yamada