Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications
Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications
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DOI：
10.1016/j.mattod.2018.11.001
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发表时间：
2019-03-01
期刊：
影响因子：
24.2
通讯作者：
Sokolov, Igor
中科院分区：
文献类型：
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作者：
Peng, Berney;Almeqdadi, Mohammad;Sokolov, Igor
醋酸纤维素（CA）、粘胶或人造丝是纤维素的生物相容性人类良性衍生物，纤维素是地球上最丰富的生物聚合物之一。虽然已经从CA开发了各种光学材料，但光学CA纳米材料是不存在的。在这里，我们报告了一个新的非常明亮的荧光CA纳米粒子（CA点），这是完全适合在体内成像/靶向应用程序的家庭的组装。CA点可以封装多种分子荧光团。使用各种市售的荧光团，我们证明CA点的荧光可以在整个UV-VIS-NIR光谱内调谐。我们还证明了在斑马鱼（人宫颈上皮癌的异种移植模型）中注射时，体内肿瘤的良好特异性靶向，以及利用CA叶酸功能化纳米颗粒在小鼠中结肠癌的异常强的体外局部标记。
Cellulose acetate (CA), viscose, or artificial silk are biocompatible human-benign derivatives of cellulose, one of the most abundant biopolymers on earth. While various optical materials have been developed from CA, optical CA nanomaterials are nonexistent. Here we report on the assembly of a new family of extremely bright fluorescent CA nanoparticles (CA-dots), which are fully suitable for in vivo imaging/targeting applications. CA-dots can encapsulate a variety of molecular fluorophores. Using various commercially available fluorophores, we demonstrate that the fluorescence of CA-dots can be tuned within the entire UV-VIS-NIR spectrum. We also demonstrate excellent specific targeting of tumors in vivo, when injected in zebrafish (xenograft model of human cervical epithelial cancer), and unusually strong exvivo topical labeling of colon cancer in mice utilizing CA folate-functionalized nanoparticles.