Adaptation Over a Wide Range of Donor Graft Lung Size Discrepancies in Living‐Donor Lobar Lung Transplantation
Adaptation Over a Wide Range of Donor Graft Lung Size Discrepancies in Living‐Donor Lobar Lung Transplantation
复制标题
活体肺叶肺移植中对各种供体肺尺寸差异的适应
DOI：
10.1111/ajt.12188
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发表时间：
2013
影响因子：
8.8
通讯作者：
H. Date
中科院分区：
文献类型：
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作者：
Fengshi Chen;T. Kubo;Tetsu Yamada;M. Sato;A. Aoyama;T. Bando;H. Date
活体肺叶移植(LDLLT)与已故供体肺移植不同，供体和受体之间的大小往往存在很大的差异。本研究的目的是评价供体肺在受体胸腔内的功能，共14例，涉及28例成功移植的下叶移植。围手术期进行肺功能检查和三维计算机断层扫描(3D-CT)。根据3D-CT尺寸匹配，供体移植物体积占受者半侧胸腔体积的40%至161%。移植物用力肺活量(FVC)值随时间延长而增加，术后12个月达到术前估计值的102±39%。移植物体积也随时间增加，术后12个月达到原值的120±38%。供体体积较小的供体移植物在LDLLT后扩张得比较大的供体移植物更大，产生的FVC值大于术前估计的值，而较大的供体移植物变得膨胀到其原始大小并保持接近术前估计的FVC值。因此，供者移植物被发现过度充气或充气不足，以使它们能够在新受者的环境中保留其固有功能。
Living‐donor lobar lung transplantation (LDLLT), unlike deceased donor lung transplantation, often involves a wide range of size discrepancies between donors and recipients. The aim of this study was to evaluate the function of donor lung grafts in the recipient thorax in 14 cases of bilateral LDLLT involving 28 successfully transplanted lower‐lobe grafts. Pulmonary function tests and three‐dimensional computed tomography (3D‐CT) volumetry were performed perioperatively. According to 3D‐CT size matching, donor graft volumes ranged from 40% to 161% of the hemilateral thoracic volumes of the recipients. Graft forced vital capacity (FVC) values increased over time, reaching 102 ± 39% of preoperatively estimated values at 12 months postoperatively. Graft volumes also increased over time, reaching 120 ± 38% of the original values at 12 months postoperatively. Undersized donor grafts expanded more after LDLLT than oversized donor grafts, producing greater FVC values than those estimated preoperatively, whereas oversized donor grafts became inflated to their original size and maintained FVC values that approached the preoperative estimates. Thus, donor grafts were found to overinflate or underinflate to the extent that they could preserve their native function in the new recipient's environment.
通过三维计算机断层扫描对右侧部分移植物进行术前估计。
DOI：
--
发表时间：
2006
期刊：
Transplant Proc 38・5
影响因子：
--
作者：
Itoh;T. et al.;竹本裕子;Satou S
通讯作者：
Satou S