Assessing the potential usefulness of IGF-related peptides and adiponectin for predicting disease risk
Assessing the potential usefulness of IGF-related peptides and adiponectin for predicting disease risk
复制标题
DOI：
10.1016/j.ghir.2007.08.005
复制
发表时间：
2008-06-01
影响因子：
1.4
通讯作者：
Saunders, Ian W.
中科院分区：
文献类型：
--
作者：
Belobrajdic, Damien P.;Priebe, Ilka K.;Saunders, Ian W.
目的：胰岛素样生长因子（IGF）及其结合蛋白和脂联素已被研究为多种疾病的潜在血液生物标志物。在这些循环蛋白质被认为是生物标志物之前，必须严格评估它们在个体内和个体间以及已发表研究之间的变化。本研究的目的是使用D值来预测IGF相关肽和脂联素作为诊断结直肠癌（CRC）的生物标志物的潜在有用性。设计图：在10名健康受试者中检查了5周内总IGF-I和IGF-II、IGF结合蛋白I（IGFBP-1）、IGFBP-2和IGFBP-3以及脂联素的个体内和个体间变异。这个数据进行了分析，结合以前的出版物，以提供一个D值，这是一个理论值，确定有用的分析物单独和作为一个小组，作为一个生物标志物为CRC.Results：一个单一的测量总IGF-I和-II，脂联素提供了一个可重复的代表他们的循环浓度。总IGF-II和IGFBP-3的D值分别为0.5和0.47，对应于64和63%的曲线下面积（AUC）值。将这些分析物组合到一个组中仅将D值略微改善至0.63（AUC为67%）。结论：虽然血清中总IGF-I、总IGF-II和IGFBP-3水平稳定且可重复，但D值计算表明，当用作CRC生物标志物时，它们的重要性有限。皇冠版权0 2007年出版的爱思唯尔有限公司保留所有权利。
Objective: Insulin-like growth factors (IGF), their binding proteins and adiponectin have been investigated as potential blood-based biomarkers for a variety of diseases. Before these circulating proteins can be considered as biomarkers, their variation within and between individuals and between published studies must be critically assessed. The purpose of this study was to use the D-value to predict the potential usefulness of IGF-related peptides and adiponectin as biomarkers for the diagnosis of colorectal cancer (CRC). Design: Intra- and inter-individual variation of total IGF-I and -II, IGF binding protein I (IGFBP-1), -2 and -3 and adiponectin, was examined in 10 healthy subjects over a 5 week period. This data was analysed in conjunction with previous publications to provide a D-value, which is a theoretical value that identifies the usefulness of the analyte individually and as a panel, as a biomarker for CRC.Results: A single measurement of total IGF-I and -II, and adiponectin provided a reproducible representation of their circulating concentrations. The D-value for total IGF-II and IGFBP-3 were 0.5 and 0.47, respectively, which corresponded to area under the curve (AUC) values of 64 and 63%. Combining these analytes into a panel only slightly improved the D-value to 0.63 (AUC was 67%). Conclusions: Although serum levels of total IGF-I total IGF-II and IGFBP-3 are stable and reproducible, the D-value calculations indicate that they have limited importance when used as biomarkers of CRC. Crown Copyright 0 2007 Published by Elsevier Ltd. All rights reserved.