Rifampin- and multidrug-resistant tuberculosis in Russian civilians and prison inmates: Dominance of the Beijing strain family
Rifampin- and multidrug-resistant tuberculosis in Russian civilians and prison inmates: Dominance of the Beijing strain family
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DOI：
10.3201/eid0811.020507
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发表时间：
2002-11-01
影响因子：
11.8
通讯作者：
Fedorin, I
中科院分区：
文献类型：
--
作者：
Drobniewski, F;Balabanova, Y;Fedorin, I
从5个俄罗斯民间和监狱结核病实验室收集结核分枝杆菌的连续患者培养物（140），并分析利福平（rpoB）和异烟肼耐药性（inhA，katG，ahpC）;北京家庭分离株的传播;以及监狱和既往治疗在耐药性中的重要性。利福平，异烟肼和多药耐药发生在58.2%，51.6%和44.7%的文化，分别为80%的监狱文化利福平耐药。Spoligotyping和可变数目串联重复序列（VNTR）指纹图谱将分离株分为43组。Spoligotyping结果显示，高比例（68.1%）的患者感染了北京家庭菌株，大多数（69.1%）是耐利福平的，最高比例（81.6%）发生在监狱。一个VNTR亚组（42435）包括68株（72.3%）具有少量IS 6110型的北京分离株; 50株（73.5%）对利福平耐药。耐利福平的北京分离株在患者人群中占主导地位，特别是在囚犯中，并威胁到治疗计划。
Consecutive patient cultures (140) of Mycobacterium tuberculosis were collected from five Russian civilian and prison tuberculosis laboratories and analyzed for rifampin (rpoB) and isoniazid resistance (inhA, katG, ahpC); transmission of Beijing family isolates; and the importance of prison and previous therapy in drug resistance. Rifampin, isoniazid, and multidrug resistance occurred in 58.2%, 51.6%, and 44.7% of cultures, respectively; 80% of prison cultures were rifampin resistant. Spoligotyping and variable number tandem repeat (VNTR) fingerprinting divided the isolates into 43 groups. Spoligotyping demonstrated that a high proportion (68.1%) of patients were infected with Beijing family strains and that most (69.1%) were rifampin resistant; the highest proportion (81.6%) occurred in prison. One VNTR subgroup (42435) comprised 68 (72.3%) of the Beijing isolates with a small number of IS6110 types; 50 (73.5%) were rifampin resistant. Rifampin-resistant Beijing isolates are dominant within the patient population, especially among prisoners, and threaten treatment programs.