Effect of Valsalva in the Pulmonary Prosthetic Conduit Valve on Hemodynamic Function in a Mock Circulatory System
Effect of Valsalva in the Pulmonary Prosthetic Conduit Valve on Hemodynamic Function in a Mock Circulatory System
复制标题
人工肺导管瓣膜中的 Valsalva 对模拟循环系统血流动力学功能的影响
DOI：
10.1109/embc.2015.7318354
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Yambe T
中科院分区：
文献类型：
--
作者：
Tsuboko Y;Shiraishi Y;Matsuo S;Yamada A;Saiki Y;Yamagishi M;Yambe T
肺动脉导管瓣膜是先天性心脏病的外科治疗方法之一。我们一直在设计一种复杂的肺动脉导管瓣膜，用于儿科患者的右心室流出道重建。本研究采用两种带或不带膨胀结构的聚酯人工血管作为管道瓣膜，并从血流动力学的角度对这些管道瓣膜在成年先天性心力衰竭患者中的应用进行了评价。我们在最初开发的肺模拟循环系统中检查了瓣膜功能，该系统由气动驱动的右心室模型、肺动脉瓣室和具有外周血管阻力单位的弹性肺顺应性模型组成。在测量之前，在每个导管中缝合双叶瓣膜。每个管道瓣膜安装在模拟右心室流出道部分，其瓣叶运动通过使用高速摄像机与压力和流量波形同步获得。结果，我们可以获得两种不同类型的管道肺动脉瓣的血流动力学变化，这表明Valsalva形状的存在可能是有效的，以促进在低心输出量条件下的瓣膜反应。
Pulmonary conduit valves are used as one of the surgical treatment methods of congenital heart diseases. We have been designing a sophisticated pulmonary conduit valve for the right ventricular outflow tract reconstruction in pediatric patients. In this study, two types of polyester grafts with or without bulging structures for the conduit valves were used and evaluated from the hemodynamic point of view focusing on the application of these conduit valves in the grown-up congenital heart failure patients. We examined valvular function in the originally developed pulmonary mock circulatory system, which consisted of a pneumatic driven right ventricular model, a pulmonary valve chamber, and an elastic pulmonary compliance model with peripheral vascular resistance units. Prior to the measurement, a bileaflet valve was sutured in each conduit. Each conduit valve was installed in the mock right ventricular outflow portion, and its leaflet motion was obtained by using a high-speed camera synchronously with pressure and flow waveforms. As a result, we could obtain hemodynamic changes in two different types of conduits for pulmonary valves, and it was indicated that the presence of the Valsalva shape might be effective for promoting valvular response in the low cardiac output condition.