Gleason grading of prostate cancer in needle biopsies or radical prostatectomy specimens: contemporary approach, current clinical significance and sources of pathology discrepancies
Gleason grading of prostate cancer in needle biopsies or radical prostatectomy specimens: contemporary approach, current clinical significance and sources of pathology discrepancies
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DOI：
10.1111/j.1464-410x.2005.05540.x
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发表时间：
2005-06-01
影响因子：
4.5
通讯作者：
Algaba, F
中科院分区：
文献类型：
--
作者：
Montironi, R;Mazzuccheli, R;Algaba, F
Gleason分级系统是诊断和帮助治疗男性前列腺癌的有力工具。针吸活检Gleason评分与几乎所有其他病理变量相关，包括根治性前列腺切除术标本中的肿瘤体积和边缘状态、血清前列腺特异性抗原水平和许多分子标志物。Gleason评分在根治性乳腺癌切除术中分配给肿瘤是根治性乳腺癌切除术后进展的最有力的预测因子。然而，这种分级制度在实践中存在重大缺陷。不仅在执业病理学家中存在问题，而且在专家中也相对缺乏观察者间的可重复性。
The Gleason grading system is a powerful tool to prognosticate and aid in the treatment of men with prostate cancer. The needle biopsy Gleason score correlates with virtually all other pathological variables, including tumour volume and margin status in radical prostatectomy specimens, serum prostate-specific antigen levels and many molecular markers. The Gleason score assigned to the tumour at radical prostatectomy is the most powerful predictor of progression after radical prostatectomy. However, there are significant deficiencies in the practice of this grading system. Not only are there problems among practising pathologists but also a relative lack of interobserver reproducibility among experts.