Thermomechanical Properties, Antibiotic Release, and Bioactivity of a Sterilized Cyclodextrin Drug Delivery System.
Thermomechanical Properties, Antibiotic Release, and Bioactivity of a Sterilized Cyclodextrin Drug Delivery System.
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DOI：
10.1039/c4tb00083h
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发表时间：
2014-05-14
期刊：
影响因子：
--
通讯作者：
von Recum HA
中科院分区：
文献类型：
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作者：
Halpern JM;Gormley CA;Keech M;von Recum HA
各种局部药物输送装置和涂层正在开发作为药物的缓慢、持续释放机制，但这些聚合物通常不会在商业灭菌技术后进行评估。我们研究了商业灭菌技术对聚氨酯聚合物的物理、机械和药物输送特性的影响。具体来说，我们在高压灭菌器、环氧乙烷和伽马辐射灭菌过程之前和之后测试了环糊精-六甲基二异氰酸酯交联聚合物。我们发现，与未灭菌的聚合物相比，经过环氧乙烷和伽马辐射灭菌的聚合物的性能没有显着变化。与未灭菌的聚合物相比，通过高压灭菌器灭菌的聚合物显示出更高的拉伸强度（p<0.0001）。在高压灭菌过程后加载的药物释放中，与未灭菌的聚合物相比，我们观察到释放时间延长（p<0.05）和治疗效果延长（p<0.05），但药物加载量较少（p<0.0001）。通过高压灭菌器灭菌的聚合物的释放曲线和拉伸强度的变化被解释为由聚合物内含有的残留的、未反应的或部分反应的交联剂的额外交联引起。因此，高压灭菌代表了额外的热处理，以改变聚氨酯和其他材料的速率和剂量。
Various local drug delivery devices and coatings are being developed as slow, sustained release mechanism for drugs, yet the polymers are typically not evaluated after commercial sterilization techniques. We examine the effect that commercial sterilization techniques have on the physical, mechanical, and drug delivery properties of polyurethane polymers. Specifically we tested cyclodextrin-hexamethyl diisocyanate crosslinked polymers before and after autoclave, ethylene oxide, and gamma radiation sterilization processes. We found that there is no significant change in the properties of polymers sterilized by ethylene oxide and gamma radiation compared to non-sterilized polymers. Polymers sterilized by autoclave showed increased tensile strength (p<0.0001) compared to non-sterilized polymers . In the release of drugs, which were loaded after the autoclave sterilization process, we observed a prolonged release (p<0.05) and a prolonged therapeutic effect (p<0.05) but less drug loading (p<0.0001) compared to non-sterilized polymers. The change in the release profile and tensile strength in polymers sterilized by autoclave was interpreted as being caused by additional crosslinking from residual, unreacted, or partially-reacted crosslinker contained within the polymer. Autoclaving therefore represents additional thermo-processing to modify rate and dose from polyurethanes and other materials.