Human cytomegalovirus induces monocyte differentiation and migration as a strategy for dissemination and persistence
Human cytomegalovirus induces monocyte differentiation and migration as a strategy for dissemination and persistence
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DOI：
10.1128/jvi.78.9.4444-4453.2004
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发表时间：
2004-05-01
影响因子：
5.4
通讯作者：
Yurochko, AD
中科院分区：
文献类型：
--
作者：
Smith, MS;Bentz, GL;Yurochko, AD
人巨细胞病毒(HCMV)的致病机制是细胞相关性病毒血症后病毒向宿主器官扩散，导致多器官系统受累。造成HCNW传播的细胞类型尚不清楚。单核细胞是最有可能的候选细胞，因为它们是血液中感染的主要细胞类型。然而，单核细胞不能产生病毒复制，并被流产感染。这里给出的结果为这个难题提供了一个潜在的答案。我们报道，单核细胞的原发HCNW感染诱导了跨内皮细胞的迁移和单核细胞向巨噬细胞的分化，这些经HCNW分化的巨噬细胞能够产生病毒复制。综上所述，我们的数据提示了一种新的HCMV致病机制：HCNW诱导单核细胞发生细胞变化，促进病毒复制并传播到宿主器官。
Human cytomegalovirus (HCMV) pathogenesis is characterized by multiple organ system involvement due to viral spread to host organs after a cell-associated viremia. The cell type responsible for HCNW dissemination is unknown. Monocytes are the most likely candidate since they are the predominant cell type infected in the blood. However, monocytes are not productive for viral replication and are abortively infected. The results presented here provide a potential answer to this conundrum. We report that primary HCNW infection of monocytes induces transendothelial migration and monocyte-to-macrophage differentiation and that these HCNW-differentiated macrophages are productive for viral replication. Together, our data suggest a novel mechanism for HCMV pathogenesis; HCNW induces cellular changes in monocytes to promote viral replication and spread to host organs.