Repeated exposure to delta 9-tetrahydrocannabinol reduces prefrontal cortical dopamine metabolism in the rat.
Repeated exposure to delta 9-tetrahydrocannabinol reduces prefrontal cortical dopamine metabolism in the rat.
复制标题
反复接触 δ9-四氢大麻酚会降低大鼠前额皮质多巴胺代谢。
DOI：
10.1016/s0304-3940(98)00254-7
复制
发表时间：
1998
影响因子：
2.5
通讯作者：
Roth,RH
中科院分区：
文献类型：
--
作者：
Jentsch,JD;Verrico,CD;Le,D;Roth,RH
人类长期滥用大麻会导致以认知和记忆障碍为特征的严重行为缺陷。特别是，据报道，大麻滥用者在依赖额叶功能的任务上存在缺陷。在目前的研究中，我们研究了长期接触大麻中的活性成分Δ9-tetrahydrocannabinol是否会改变大鼠额叶皮层的神经化学。两周的Δ9-tetrahydrocannabinol治疗减少了内侧前额叶皮层的多巴胺传递，而纹状体区域的多巴胺代谢不受影响。这些数据与早期多巴胺能调节额叶皮质认知的发现一致。因此，重度大麻滥用者的认知缺陷可能是由药物引起的额叶皮质多巴胺传递的改变所引起的。
Long-term abuse of marijuana by humans can induce profound behavioral deficits characterized by cognitive and memory impairments. In particular, deficits on tasks dependent on frontal lobe function have been reported in cannabis abusers. In the current study, we examined whether long-term exposure to Δ9-tetrahydrocannabinol, the active ingredient in marijuana, altered the neurochemistry of the frontal cortex in rats. Two weeks administration of Δ9-tetrahydrocannabinol reduced dopamine transmission in the medial prefrontal cortex, while dopamine metabolism in striatal regions was unaffected. These data are consistent with earlier findings of dopaminergic regulation of frontal cortical cognition. Thus, cognitive deficits in heavy abusers of cannabis may be subserved by drug-induced alterations in frontal cortical dopamine transmission.