Rising incidence of primary central nervous system lymphoma in Kumamoto, Japan
Rising incidence of primary central nervous system lymphoma in Kumamoto, Japan
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DOI：
10.1016/j.surneu.2006.05.055
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发表时间：
2006-11-01
影响因子：
--
通讯作者：
Kuratsu, Jun-ichi
中科院分区：
文献类型：
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作者：
Makino, Keishi;Nakamura, Hideo;Kuratsu, Jun-ichi
背景：原发性中枢神经系统淋巴瘤是一种发生在锁骨脊髓轴的结外形式的非霍奇金淋巴瘤。据报道，在过去的20年里，PCNSL的发病率在世界一些地区呈上升趋势。方法：我们调查了1989-2004年间诊断为PIT的4007例患者，其中70%的患者获得了组织学诊断。结果：4007例患者中，136例(3.4%)确诊为PCNSL。这一时期的年龄调整发病率为0.41/10万/年，高于至1998年的0.29/10万/年。此外，PCNSL患者的数量翻了一番，从(1996年)的45人增加到1997年至2004年的91人。结论：我们的发现表明熊本县免疫功能正常的人中PCNSL的发病率有所增加。(C)2006 Elsevier Inc.保留所有权利。
Background: Primary central nervous system lymphoma is an extranodal form of non-Hodgkin lymphoma arising in the cramospinal axis. The incidence of PCNSL is reportedly on the increase in some parts of the world in the last 2 decades.Methods: We surveyed 4007 patients diagnosed with PIT between 1989 and 2004, with histologic diagnosis being obtained in 70% of the patients. Of these, the PCNSL cases were reviewed.Results: Of 4007, 136 (3.4%) carried a diagnosis of PCNSL. At 0.41 per 100,000 per year, the age-adjusted incidence rate for that period was higher than that for the period from 1989 to 1998 (0.29 per 100,000 per year). Moreover, the number of patients with PCNSL doubled from 45 (1989-1996) to 91 (1997-2004).Conclusions: Our findings point to an increase in the incidence of PCNSL among immunocompetent individuals in Kumamoto Prefecture. (c) 2006 Elsevier Inc. All rights reserved.