Measurement of retinal vascular tortuosity and its application to retinal pathologies
Measurement of retinal vascular tortuosity and its application to retinal pathologies
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DOI：
10.1007/s11517-009-0559-4
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发表时间：
2010-01-01
影响因子：
3.2
通讯作者：
Wiers, Matthew D.
中科院分区：
文献类型：
--
作者：
Dougherty, Geoff;Johnson, Michael J.;Wiers, Matthew D.
视网膜血管扭曲是许多视网膜病变的重要诊断指标。我们应用了非常适合自动检测和测量的稳健定量扭曲度量，用于显示背景糖尿病视网膜病变、视网膜色素变性和视网膜血管炎的正常和病变血管的视网膜荧光素图像。我们建立了平均扭曲度(M)和标准化均方根扭曲度(K)的有效性，因为它们与眼科专家小组对扭曲度的排名有很强的相关性。一般人群中疾病的低患病率影响了分类过程，并排除了在一般人群中同时使用扭曲筛查所有这些疾病的可能性。弯曲度可作为单独视网膜炎的筛查试验，也可用于在任意（即转诊）人群中区分糖尿病视网膜病变或血管炎与正常人。
The tortuosity of retinal blood vessels is an important diagnostic indicator for a number of retinal pathologies. We applied robust quantitative tortuosity metrics, which are well suited to automated detection and measurement, to retinal fluorescein images of normal and diseased vessels exhibiting background diabetic retinopathy, retinitis pigmentosa and retinal vasculitis. We established the validity of the mean tortuosity (M) and the normalized root-mean-square tortuosity (K) by their strong correlation with the ranking of tortuosity by an expert panel of ophthalmologists. The low prevalences of the diseased conditions in the general population affect the classification process, and preclude the use of tortuosity for screening for all of these conditions simultaneously in the general population. Tortuosity may be useful as a screening test for retinitis alone, and may be useful for distinguishing diabetic retinopathy or vasculitis from normal in a discretionary (i.e. referred) population.