Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development
Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development
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DOI：
10.1242/dev.00904
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发表时间：
2003-12-01
期刊：
影响因子：
4.6
通讯作者：
Cohen, SM
中科院分区：
文献类型：
--
作者：
Giraldez, AJ;Cohen, SM
动物发育过程中的组织生长依赖于细胞增殖和细胞死亡的协调。EGF受体/MAPK、Hedgehog、DPP、Wingless(Wg)和Notch信号通路参与了果蝇翅膀发育的生长控制。在这份报告中，我们研究了Notch和Wg在细胞增殖和细胞存活方面对生长的影响。Wg信号的减少损害了隔室和克隆性生长，并增加了细胞死亡。抑制Wg信号缺乏的细胞的凋亡只能部分挽救克隆生长缺陷，这表明Wg也是促进细胞增殖所必需的。Wg的异位表达导致了近侧翼细胞的过度增殖，这一发现支持了这一点。Notch的局部激活对细胞增殖具有非自主性作用。然而，这种效应只有一部分归因于Notch依赖的Wg的诱导，这表明其他Notch诱导的信号分子有助于控制翅膀中的细胞增殖。
Tissue growth during animal development depends on the coordination of cell proliferation and cell death. The EGF-receptor/MAPK, Hedgehog, Dpp, Wingless (Wg) and Notch signaling pathways have been implicated in growth control in the developing Drosophila wing. In this report, we examine the effects of Notch and Wg on growth in terms of cell proliferation and cell survival. Reduction of Wg signaling impaired compartment and clonal growth, and increased cell death. Inhibition of apoptosis in cells deficient for Wg signaling only partially rescued the clone growth defect, suggesting that Wg is also required to promote cell proliferation. This is supported by the finding that ectopic expression of Wg caused over-proliferation of cells in the proximal wing. Localized activation of Notch had non-autonomous effects on cell proliferation. However, only part of this effect was attributable to Notch-dependent induction of Wg, suggesting that other Notch-inducible signaling molecules contribute to the control of cell proliferation in the wing.