Significance of and risk factors for the development of central airway stenosis after lung transplantation.
Significance of and risk factors for the development of central airway stenosis after lung transplantation.
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DOI：
10.1111/ajt.12017
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发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Snyder LD
中科院分区：
文献类型：
--
作者：
Shofer SL;Wahidi MM;Davis WA;Palmer SM;Hartwig MG;Lu Y;Snyder LD
肺移植后中央气道狭窄（CAS）是一种鲜为人知的并发症。本研究的目的是确定CAS是否与移植后慢性排斥反应或更差的生存率相关，并在一个大型肺移植受者队列中确定与CAS相关的因素。在单中心移植的肺移植受者对需要气道扩张的CAS的发展进行回顾性回顾。467名受试者符合纳入标准，其中60名（13%）发展中CAS需要干预。在这60例患者中，22例（37%）仅通过支气管成形术解决了CAS，而32例（53%）最终需要支架置入。需要干预的CAS不是闭塞性细支气管炎综合征发展或更差的总生存的危险因素。在时间依赖的多变量模型中，肺真菌感染和术后气管切开术的需要是随后发生CAS的重要危险因素。虽然CAS与BOS或更差的生存率无关，但它仍然是肺移植后重要的并发症，具有潜在的可预防的危险因素。
Central airways stenosis (CAS) after lung transplant is a poorly understood complication. Objectives of this study were to determine if CAS was associated with chronic rejection or worse survival after transplant as well as to identify factors associated with CAS in a large cohort of lung transplant recipients. Lung transplant recipients transplanted at a single center were retrospectively reviewed for the development of CAS requiring airway dilation. 467 subjects met inclusion criteria with 60 (13%) of these developing CAS requiring intervention. Of these 60 recipients, 22 (37%) had resolution of CAS with bronchoplasty alone, while 32 (53%) ultimately required stent placement. CAS that required intervention was not a risk factor for the development of bronchiolitis obliterans syndrome or worse overall survival. Significant risk factors for the subsequent development of CAS in a time-dependant multivariable model were pulmonary fungal infections and the need for post-operative tracheostomy. While CAS was not associated with BOS or worse survival, it remains an important complication after lung transplant with potentially preventable risk factors.
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影响因子：
3.4
作者：
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通讯作者：
Salvatierra, A
影响因子：
9.6
作者：
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DOI：
10.1513/pats.200808-094go
发表时间：
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期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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