Acute mountain sickness is not altered by a high carbohydrate diet nor associated with elevated circulating cytokines.
Acute mountain sickness is not altered by a high carbohydrate diet nor associated with elevated circulating cytokines.
复制标题
DOI：
--
复制
发表时间：
1997-06
期刊：
影响因子：
--
通讯作者：
Erik R. Swenson;Alistair MacDonald;Martin Vatheuer;Christine Maks;Allen Treadwell;Roblee P. Allen;Robert B. Schoene
中科院分区：
文献类型：
--
作者：
Erik R. Swenson;Alistair MacDonald;Martin Vatheuer;Christine Maks;Allen Treadwell;Roblee P. Allen;Robert B. Schoene
我们研究了增加碳水化合物含量的饮食是否会减轻急性高原病（AMS）的症状，以及循环细胞因子浓度是否升高并与缺氧和AMS相关。有19名健康志愿者，他们以随机顺序摄入高碳水化合物（68% CHO）或正常碳水化合物（45% CHO）饮食4天。在第4天，受试者暴露于10%常压氧气8小时。每位受试者在每次缺氧期开始和结束时完成路易斯湖共识问卷（LLCQ：一份量化AMS常见症状和后果的问卷），同时获得静脉血中以下细胞因子：白细胞介素1 β、6和8 （IL-1 β、IL-6、IL-8）和肿瘤坏死因子α (tnf - α)。两种饮食之间AMS症状无显著差异（LLCQ评分：68% CHO = 10.1 +/- 3.8 vs. 45% CHO = 10.3 +/- 4.1）。细胞因子浓度不随两种饮食的缺氧而改变，个体变化也不与AMS症状相关。我们的结论是，高碳水化合物饮食4 d并不能减轻AMS的症状；血浆细胞因子浓度不随缺氧和AMS的发展而改变，因此不可能是该综合征的介质。
We investigated whether a diet of increased carbohydrate content reduces the symptoms of acute mountain sickness (AMS) and whether concentrations of circulating cytokines rise and correlate with hypoxia and AMS. There were 19 healthy volunteers who ingested in randomized order both a high carbohydrate (68% CHO) or normal carbohydrate (45% CHO) diet for 4 d. On the 4th d, subjects were exposed to 8 h of 10% normobaric oxygen. Each subject completed the Lake Louise Consensus Questionnaire (LLCQ: a questionnaire developed to quantify the common symptoms and consequences of AMS) at the beginning and end of each hypoxic session, at which times venous blood was obtained for the following cytokines: interleukins 1 beta, 6 and 8 (IL-1 beta, IL-6, IL-8) and tumor necrosis factor alpha (TNF-alpha). AMS symptoms did not differ significantly between the diets (LLCQ scores: 68% CHO = 10.1 +/- 3.8 vs. 45% CHO = 10.3 +/- 4.1). Cytokine concentrations did not change with hypoxia on either diet, nor did individual changes correlate with AMS symptoms. We conclude that a high carbohydrate diet for 4 d does not reduce the symptoms of AMS; and plasma cytokine concentrations do not change with hypoxia and the development of AMS and, thus, are not likely mediators of this syndrome.