Close yet independent: Dissociation of social from valence and abstract semantic dimensions in the left anterior temporal lobe
Close yet independent: Dissociation of social from valence and abstract semantic dimensions in the left anterior temporal lobe
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紧密而独立：左前颞叶的社会性与效价和抽象语义维度的分离
DOI：
10.1002/hbm.24735
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发表时间：
2019
影响因子：
4.8
通讯作者：
Bi Yanchao
中科院分区：
文献类型：
--
作者：
Wang Xiaosha;Wang Bijun;Bi Yanchao
前颞叶（ATL）参与各种类型的语义维度。一个一贯报道的方面是社会信息，抽象的话描述社会行为诱导更强的激活ATL比非社会的话。在这一发现中，一个潜在的因素被系统地混淆了，那就是情感效价，因为抽象的社交词汇往往与情感有关。我们采用2（社会/非社会）× 2（效价/中性）析因设计，在相对高空间分辨率的fMRI研究中研究了哪些因素驱动ATL敏感性。我们发现，社会性和效价加工在不同的ATL区域没有显着的相互作用：社会效应被发现在左前上级颞沟（aSTS），而效价效应激活小集群的双边颞极（TP）。在左侧ATL中，社交和效价相关的集群与另一个上级ATL区域不同，后者表现出一般的“抽象”效应，几乎没有社交或效价的调节。这些子区域在静息状态下表现出不同的全脑功能连接模式，社交集群功能连接到默认模式网络，效价集群连接到相邻的颞区和杏仁核，抽象集群连接到一个分布式网络，包括一组语言相关区域。这些激活特征和连接模式的结果共同表明，左ATL支持语义处理的方式是高度细粒度的，社会语义效应的神经基质与情感效价和抽象性的神经基质分离。
The anterior temporal lobe (ATL) is engaged in various types of semantic dimensions. One consistently reported dimension is social information, with abstract words describing social behaviors inducing stronger activations in the ATL than nonsocial words. One potential factor that has been systematically confounded in this finding is emotional valence, given that abstract social words tend to be associated with emotional feelings. We investigated which factors drove the ATL sensitivity using a 2 (social/nonsocial) × 2 (valenced/neutral) factorial design in an fMRI study with relatively high spatial resolutions. We found that sociality and valence were processed in different ATL regions without significant interactions: The social effect was found in the left anterior superior temporal sulcus (aSTS), whereas the valence effect activated small clusters in the bilateral temporal poles (TP). In the left ATL, the social‐ and valence‐related clusters were distinct from another superior ATL area that exhibited a general “abstractness” effect with little modulation of sociality or valence. These subregions exhibited distinct whole‐brain functional connectivity patterns during the resting state, with the social cluster functionally connected to the default mode network, the valence cluster connected to the adjacent temporal regions and amygdala, and the abstractness cluster connected to a distributed network including a set of language‐related regions. These results of activation profiles and connectivity patterns together indicate that the way in which the left ATL supports semantic processing is highly fine‐grained, with the neural substrate for social semantic effects dissociated from those for emotional valence and abstractness.