Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
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DOI：
10.1126/science.285.5428.727
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发表时间：
1999-07-30
期刊：
影响因子：
56.9
通讯作者：
Spies, T
中科院分区：
文献类型：
--
作者：
Bauer, S;Groh, V;Spies, T
应激诱导的MICA是主要组织相容性复合体(MHC)I类的一种遥远的同系物，作为γ-Delta T细胞的抗原，经常在上皮性肿瘤中表达。MICA受体在大多数γ-βT细胞、CD8(+)α-βT细胞和自然杀伤(NK)细胞上被检测到，并被鉴定为NKG2D。所有这些亚群的效应细胞均可被NKG2D结扎刺激。NKG2D激活T细胞和NK细胞对转染者和表达MICA的上皮性肿瘤细胞的杀伤反应。这些结果确定了一种激活的免疫受体-MHC配体相互作用，可能促进抗肿瘤的NK和T细胞反应。
Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for gamma delta T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most gamma delta T cells, CD8(+) alpha beta T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gamma delta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.