Residual cognitive deficits 50 years after lead poisoning during childhood.
Residual cognitive deficits 50 years after lead poisoning during childhood.
复制标题
儿童期铅中毒 50 年后残留认知缺陷。
DOI：
10.1136/oem.50.7.613
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Hu,H
中科院分区：
文献类型：
--
作者：
White,RF;Diamond,R;Proctor,S;Morey,C;Hu,H
儿童铅中毒的长期神经行为后果尚不清楚。在这项研究中，4岁以前有铅中毒病史的成人受试者和匹配的对照组接受了一系列简短的神经心理学测试，包括注意力、推理、记忆、运动速度和当前情绪的测量。接触铅的受试者在几乎所有认知任务上的表现都不如对照组。这种广泛的缺陷模式类似于急性铅暴露时在儿童中发现的，而不是在接触铅的成年人中通常看到的更有限的模式。尽管与对照组一样完成了多年的学校教育，但接触铅的受试者的终身职业地位较低。在暴露组中，神经心理电池的表现与职业状态相关，与假设的神经心理功能限制对日常生活的影响一致。结果表明，许多暴露于铅的受试者在儿童时期患有急性脑病，并在成年后演变为慢性亚临床脑病，并伴有明显的认知功能障碍。这些发现为限制儿童接触铅的努力提供了支持。
The long term neurobehavioural consequences of childhood lead poisoning are not known. In this study adult subjects with a documented history of lead poisoning before age 4 and matched controls were examined with an abbreviated battery of neuropsychological tests including measures of attention, reasoning, memory, motor speed, and current mood. The subjects exposed to lead were inferior to controls on almost all of the cognitive tasks. This pattern of widespread deficits resembles that found in children evaluated at the time of acute exposure to lead rather than the more circumscribed pattern typically seen in adults exposed to lead. Despite having completed as many years of schooling as controls, the subjects exposed to lead were lower in lifetime occupational status. Within the exposed group, performance on the neuropsychological battery and occupational status were related, consistent with the presumed impact of limitations in neuropsychological functioning on everyday life. The results suggest that many subjects exposed to lead suffered acute encephalopathy in childhood which resolved into a chronic subclinical encephalopathy with associated cognitive dysfunction still evident in adulthood. These findings lend support to efforts to limit exposure to lead in childhood.