Heterogeneity in hippocampal place coding
Heterogeneity in hippocampal place coding
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DOI：
10.1016/j.conb.2018.02.014
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发表时间：
2018-04-01
影响因子：
5.7
通讯作者：
Giocomo, Lisa M.
中科院分区：
文献类型：
--
作者：
Mallory, Caitlin S.;Giocomo, Lisa M.
位置细胞的发现为海马体编码空间记忆和支持导航的神经基础提供了基本的见解，并促进了计算模型的发展，以解释其空间选择性的出现。许多这样的作品都认为，来自内嗅网格细胞的输入对位置场的形成至关重要，这一预测得到了混合实验的支持。最近的研究可能会调和看似矛盾的发现，表明锥体神经元的亚群在功能上是不同的，可能会受到不同输入的不同程度的驱动。此外，新的研究表明，海马主要神经元编码的功能扩展到当前位置以外的无数。在这里，我们强调了最近的证据，如何广泛的异质性连接和基因表达可以与膜生物物理相互作用，使定位细胞编码各种各样的刺激。这些最近的研究结果强调了需要更多的计算模型，整合海马主要神经元的这些异质性特征。
The discovery of place cells provided fundamental insight into the neural basis by which the hippocampus encodes spatial memories and supports navigation and prompted the development of computational models to explain the emergence of their spatial selectively. Many such works posit that input from entorhinal grid cells is critical to the formation of place fields, a prediction that has received mixed experimental support. Potentially reconciling seemingly conflicting findings is recent work indicating that subpopulations of pyramidal neurons are functionally distinct and may be driven to varying degrees by different inputs. Additionally, new studies have demonstrated that hippocampal principal neurons encode a myriad of features extending beyond current position. Here, we highlight recent evidence for how extensive heterogeneity in connectivity and genetic expression could interact with membrane biophysics to enable place cells to encode a diverse range of stimuli. These recent findings highlight the need for more computational models that integrate these heterogeneous features of hippocampal principal neurons.