Progranulin is a novel biomarker for predicting an acute exacerbation of chronic obstructive pulmonary disease
Progranulin is a novel biomarker for predicting an acute exacerbation of chronic obstructive pulmonary disease
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颗粒体蛋白前体是一种用于预测慢性阻塞性肺疾病急性加重的新型生物标志物
DOI：
10.1111/crj.12952
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发表时间：
2018-10-01
影响因子：
1.7
通讯作者：
Pan, Jue
中科院分区：
文献类型：
--
作者：
Chen, Xiaoyan;Liu, Jinguo;Pan, Jue
前粒蛋白是一种多效性糖基化蛋白前体，在炎症反应中发挥重要作用。目的：探讨血浆原颗粒蛋白在慢性阻塞性肺疾病急性加重期(AECOPD)中的作用。方法检测52例AECOPD患者、56例稳定期COPD患者和36例健康人血浆原颗粒蛋白水平。AECOPD患者在入院最后一天重复测定血浆前颗粒蛋白水平。结果AECOPD患者血浆PRO水平明显高于稳定期COPD患者和健康对照组(分别为158.7748.17,109.00±25.05，93.67+/-14.71 ng/mL，P
BackgroundProgranulin is a pleiotropic glycosylated protein precursor that plays an important role in inflammation. Limited data exist regarding the role of progranulin in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD).ObjectivesMethodsThe study is to assess the efficiency of progranulin as a circulating biomarker of AECOPD.The plasma progranulin levels were measured and compared in patients with AECOPD (n=52), patients with stable COPD (n=56), and healthy controls (n=36). In patients with AECOPD, plasma progranulin levels were measured repeatedly on the last day of hospitalization. Demographical data, pulmonary function, and laboratory parameters were recorded.ResultsConclusionsPatients with AECOPD had higher plasma progranulin levels than both stable COPD patients and healthy controls (158.7748.17, 109.00 +/- 25.05, 93.67 +/- 14.71ng/mL, respectively; P