Vasoactive intestinal polypeptide-like substance: the potential transmitter for cerebral vasodilation.
Vasoactive intestinal polypeptide-like substance: the potential transmitter for cerebral vasodilation.
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血管活性肠多肽样物质：脑血管舒张的潜在递质。
DOI：
10.1126/science.6719122
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Berezin,I
中科院分区：
文献类型：
--
作者：
Lee,TJ;Saito,A;Berezin,I
体外药理研究表明，外源性应用血管活性肠肽(VIP)可松弛猫脑动脉的平滑肌细胞，而P物质则使其收缩。超微结构免疫细胞化学技术显示，在大脑动脉壁的非交感神经轴突和终末的大颗粒囊泡中存在VIP样物质。这些结果提供了强有力的证据，支持VIP样物质是脑血管中血管扩张的递质的假设。
In vitro pharmacological studies demonstrated that exogenously applied vasoactive intestinal polypeptide (VIP) relaxes the smooth muscle cells of cat cerebral arteries, whereas substance P constricts them. Ultrastructural-immunocytochemical techniques show that a VIP-like substance is present in the large granular vesicles of nonsympathetic nerve axons and terminals in the cerebral arterial walls. These results provide strong evidence in favor of the hypothesis that a VIP-like substance is the transmitter for vasodilation in cerebral blood vessels.