Stool calprotectin in necrotizing enterocolitis.
Stool calprotectin in necrotizing enterocolitis.
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DOI：
10.4103/2249-4847.128721
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发表时间：
2014-01
影响因子：
0.2
通讯作者：
Awad HA
中科院分区：
文献类型：
--
作者：
Albanna EA;Ahmed HS;Awad HA
钙卫蛋白是存在于中性粒细胞的细胞质中的36kDa蛋白质，具有抗微生物和凋亡诱导活性。体外研究表明，钙卫蛋白抑制各种微生物的生长。坏死性小肠结肠炎（NEC）仍然是新生儿重症监护病房（NICU）发病率和死亡率的主要原因之一，影响高达5%的早产儿。粪便钙卫蛋白对降解具有抗性，已被提议作为胃肠道炎症的有用标志物。本研究的目的是评价NEC的粪便钙卫蛋白浓度。15名临床诊断为NEC的新生儿进行了研究，他们在Zagazig大学医院的NICU住院。另取20例年龄、性别相匹配的新生儿作为对照组，给予全热量喂养.所有新生儿均接受病史采集、临床检查、实验室检查（全血细胞计数、C反应蛋白）和粪便钙卫蛋白测定。患者粪便钙卫蛋白水平比对照组显著升高，死亡患者粪便钙卫蛋白水平比存活患者显著升高。随着NEC严重程度的增加，粪便钙卫蛋白水平也显著增加。粪便钙卫蛋白的测量可能是一个有价值的工具，早产儿和足月婴儿怀疑有NEC的调查。
Calprotectin is a 36 kDa protein present in the cytoplasm of the neutrophil has antimicrobial and apoptosis inducing activities. In vitro studies have shown that calprotectin inhibits the growth of various microorganisms. Necrotizing enterocolitis (NEC) remains one of the leading causes of morbidity and mortality in neonatal intensive care units (NICU), affecting up to 5% of premature infants. Fecal calprotectin is resistant to degradation and has been proposed as a useful marker of gastrointestinal inflammation. The objective of the present study is to evaluate fecal calprotectin concentrations in NEC. Fifteen neonates with a clinical diagnosis of NEC were studied; they admitted at NICU of Zagazig University Hospital. In addition, 20 age sex matched neonates fed all caloric requirement served as the control group. All neonates were subjected to history taking, clinical examination, laboratory investigations (complete blood count, C-reactive protein) and determination of stool calprotectin. There was a highly significant increase in fecal calprotectin in patients than control and there was a highly significant increase in its fecal level in died patients than living one. Also significant increase in fecal calprotectin level with increasing severity of NEC. Fecal calprotectin measurements could be a valuable tool for the investigation of preterm and full term infants suspected of having NEC.