Two distinct gamma-2 herpesviruses in African green monkeys: A second gamma-2 herpesvirus lineage among old world primates?
Two distinct gamma-2 herpesviruses in African green monkeys: A second gamma-2 herpesvirus lineage among old world primates?
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DOI：
10.1128/jvi.74.3.1572-1577.2000
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发表时间：
2000-02-01
影响因子：
5.4
通讯作者：
Schulz, TF
中科院分区：
文献类型：
--
作者：
Greensill, J;Sheldon, JA;Schulz, TF
灵长类动物γ -2疱疹病毒（横纹肌病毒）迄今已在人类（卡波西肉瘤相关疱疹病毒[KSHV]，也称为人类疱疹病毒8）、猕猴（猕猴属）（恒河猴横纹肌病毒[RRV]和腹膜后纤维瘤病疱疹病毒[RFHV]）、松鼠猴（猴猴属）（猴猴属）和蜘蛛猴（猴猴属）（猴猴属）（猴猴属）（猴猴属）（猴猴属）（猴猴属）（疱疹病毒）中被发现。我们在非洲绿猴中检测到两种不同的γ -2疱疹病毒序列，分别称为绿头腺病毒1 （ChRV1）和ChRV2。ChRV1与KSHV和RFHV的关系更为密切，而ChRV2与RRV的关系最为密切。我们的研究结果表明，至少在两个旧大陆猴物种中存在两种不同的横线病毒谱系，分别以KSHV/RFHV/ChRV1组和RRV/ChRV2组为代表。针对RRV/ChRV2谱系成员的抗体可能在早期和晚期KSHV抗原的免疫荧光检测中交叉反应。
Primate gamma-2 herpesviruses (rhadinoviruses) have so far been found in humans (Kaposi's sarcoma-associated herpesvirus [KSHV], also called human herpesvirus 8), macaques (Macaca spp.) (rhesus rhadinovirus [RRV] and retroperitoneal fibromatosis herpesvirus [RFHV]), squirrel monkeys (Saimiri sciureus) (herpesvirus saimiri), and spider monkeys (Ateles spp.) (herpesvirus ateles), Using serological screening and degenerate consensus primer PCR for the viral DNA polymerase gene, we have detected sequences from two distinct gamma-2 herpesviruses, termed Chlorocebus rhadinovirus 1 (ChRV1) and ChRV2, in African green monkeys. ChRV1 is more closely related to KSHV and RFHV, whereas ChRV2 is closest to RRV. Our findings suggest the existence of two distinct rhadinovirus lineages, represented by the KSHV/RFHV/ChRV1 group and the RRV/ChRV2 group, respectively, in at least two Old World monkey species. Antibodies to members of the RRV/ChRV2 lineage may cross-react in an immunofluorescence assay for early and late KSHV antigens.