Effect of percutaneous transluminal coronary angioplasty on exercise ventilation in patients with coronary artery disease and normal left ventricular function
Effect of percutaneous transluminal coronary angioplasty on exercise ventilation in patients with coronary artery disease and normal left ventricular function
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DOI：
10.1016/s0002-8703(96)90389-0
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发表时间：
1996-07-01
影响因子：
4.8
通讯作者：
Sugishita, Y
中科院分区：
文献类型：
--
作者：
Ajisaka, R;Watanabe, S;Sugishita, Y
我们对22例左心室收缩功能正常的冠心病（CAD）患者行经皮腔内冠状动脉成形术（PTCA）前后运动对通气反应的影响进行了评价，以确定运动性心肌缺血对通气反应的影响。受试者在坐姿下进行了症状限制的最大测力仪运动测试。根据运动时的分钟通气斜率（Voverdot(E)）和二氧化碳生成斜率（VoverdotCO(2)）（斜率1和斜率2，分别定义为低于和高于呼吸代偿阈值）来评估通气反应。CAD患者（Voverdot(E)）与（VoverdotCO(2)）的斜率1相关性（27.3 +/- 2.6）明显大于同龄对照组（23.7 +/- 2.6,p < 0.01）。患者的斜率2（41.0 +/- 4.8）也显著高于对照组（29.7 +/- 2.9,p < 0.01）。14例PTCA成功的患者（Voverdot(E)）与（VoverdotCO(2)）的斜率1相关性显著降低，而8例PTCA失败的患者斜率1相关性不降低。我们的研究结果表明，心肌缺血增加冠心病患者左心室收缩功能正常的运动通气，其作用是可逆的。
We evaluated the ventilatory response to exercise before and after percutaneous transluminal coronary angioplasty (PTCA) in 22 patients with coronary artery disease (CAD) and normal left ventricular systolic function to determine the effect of exercise-induced myocardial ischemia on the ventilatory response. Subjects performed a symptom-limited maximal ergometer exercise test in the sitting position. The ventilatory response was evaluated in terms of the slopes of minute ventilation (Voverdot(E)) and carbon dioxide production (VoverdotCO(2)) during exercise (slope 1 and slope 2, defined as below and above the respiratory compensation threshold, respectively). Slope 1 of the correlation between (Voverdot(E)) and (VoverdotCO(2)) was significantly greater in patients with CAD (27.3 +/- 2.6) than in the age-matched control group (23.7 +/- 2.6; p < 0.01). Slope 2 was also significantly greater in patients (41.0 +/- 4.8) than in the control group (29.7 +/- 2.9; p < 0.01). Slope 1 of the correlation between (Voverdot(E) and (VoverdotCO(2)) decreased significantly in the 14 patients in whom PTCA was successful but did not decrease in the 8 patients in whom PTCA failed. Our results suggest that myocardial ischemia increases exercise ventilation in patients with CAD and normal left ventricular systolic function and that its effect is reversible.