Hepatic immunosuppressive effects of systemically administered novel dextran-methylprednisolone prodrugs with peptide linkers in rats.
Hepatic immunosuppressive effects of systemically administered novel dextran-methylprednisolone prodrugs with peptide linkers in rats.
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具有肽接头的新型右旋糖酐-甲基泼尼松龙前药对大鼠全身给药的肝脏免疫抑制作用。
DOI：
10.1002/jps.23274
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发表时间：
2012
影响因子：
3.8
通讯作者：
Mehvar,Reza
中科院分区：
文献类型：
--
作者：
Shaik,ImamH;Agarwal,HiteshK;Parang,Keykavous;Mehvar,Reza
研究了以1个氨基酸(DMP1)和5个氨基酸(DMP5)为连接基的两种新型葡聚糖前药甲基强的松龙(MP)对大鼠肝脏的免疫抑制作用。在不同时间(0-2周)静脉注射每种前药5 mg/kg(MP当量)或MP琥珀酸酯(MPS)后，分离肝脏，用脂多糖免疫刺激活体。测定出口灌流液中肿瘤坏死因子-α的浓度以评估免疫反应。此外，还测量了肝脏中DMP1、DMP5和/或MP的浓度。MPS、DMP5和DMP1可使α分泌减少48.9%、63.5%和85.7%，抑制作用超过50%的时间分别为5h、24h和120h。此外，DMP1的作用-时间曲线下面积分别是MPS或DMP5给药后的11倍和4倍。即使在最后两周的采样时间，肝脏中也存在相对较高浓度的DMP1。这些数据表明，单次静脉注射DMP1可在较长时间内在肝脏产生强烈和持续的免疫抑制，这可能对肝移植有用。
The hepatic immunosuppressive activities of two novel dextran prodrugs of methylprednisolone (MP) containing one (DMP1) or five (DMP5) amino acids as linkers were studied in rats. At various times (0–2 weeks) after intravenous administration of single 5 mg/kg (MP equivalent) doses of each prodrug or MP succinate (MPS), livers were isolated and immunologically stimulatedex vivowith lipopolysaccharide. The concentrations of tumor necrosis factor (TNF)‐α in the outlet perfusate were then quantitated to assess immune response. Additionally, the concentrations of DMP1, DMP5, and/or MP were measured in the liver. MPS, DMP5, or DMP1 injections caused a maximum of 48.9%, 63.5%, or 85.7% decrease in the TNF‐α secretion into the perfusate, with the time above the 50% inhibitory effect being <5, <24, or 120 h, respectively. Additionally, the area under the effect–time curve for DMP1 was 11‐fold or fourfold higher than that after the administration of MPS or DMP5, respectively. Relatively high concentrations of DMP1 were present in the liver even at the last sampling time of 2 weeks. These data suggest that a single intravenous dose of DMP1 produces an intense and sustained immunosuppression in the liver for a relatively long time, which may be useful in liver transplantation.
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局部免疫抑制的情况。
影响因子：
6.2
作者：
S. Gruber
通讯作者：
S. Gruber
急性心脏排斥患者使用体外膜氧合法抢救甲强龙冲击治疗后心脏骤停：两例病例报告。
影响因子：
0.9
作者：
M. L. Lee;N. Chou;W. Ko;N. Chi;Y. Chen;H. Y. Yu;I. Wu;S. C. Huang;C. Wang;C. I. Chang;S. S. Wang
通讯作者：
S. S. Wang
使用肾脏靶向泼尼松龙前药进行局部免疫抑制可延长大鼠肾同种异体移植物的存活率。
影响因子：
0.9
作者：
M. Su;Z. Li;Z. Zhang;G. Feng
通讯作者：
G. Feng
暴露于内毒素和地塞米松的大鼠中肿瘤坏死因子的产生和清除。
DOI：
10.1016/0090-1229(87)90087-0
发表时间：
1987
期刊：
Clinical immunology and immunopathology
影响因子：
--
作者：
A. Waage
通讯作者：
A. Waage
甲泼尼龙静脉冲击治疗后室上性心动过速的首次报告，并简要回顾文献
影响因子：
4
作者：
R. Kumari;S. Uppal
通讯作者：
S. Uppal