Interleukin-10 or tumor necrosis factor-α polymorphisms and the natural course of hepatitis C virus infection in a hyperendemic area of Japan
Interleukin-10 or tumor necrosis factor-α polymorphisms and the natural course of hepatitis C virus infection in a hyperendemic area of Japan
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DOI：
10.1016/j.cyto.2006.03.011
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发表时间：
2006-04-01
期刊：
影响因子：
3.8
通讯作者：
Tsubouchi, Hirohito
中科院分区：
文献类型：
--
作者：
Kusumoto, Kazunori;Uto, Hirofumi;Tsubouchi, Hirohito
我们研究了日本社区人群中白细胞介素(IL)-10和肿瘤坏死因子(TNF)- α多态性对丙型肝炎病毒（HCV）感染自然过程的影响。将460例抗HCV抗体血清阳性个体分为HCV RNA阳性和阴性两组。在1993年至2003年间每年至少进行四次丙氨酸氨基转移酶（ALT）检测的HCV rna阳性个体中，74例ALT水平持续正常，211例ALT水平一次或多次升高。我们研究了编码IL-10（-1082, -819, -592）或tnf - α(-308, -238)的基因多态性与HCV清除率、ALT异常或血清IV型胶原7S（肝纤维化标志物）水平之间的关系。这些多态性在不同HCV RNA清除率或ALT异常的患者亚组中均匀分布。然而，在tnf - α基因启动子-238或-308位置有A的个体血清中IV型胶原7S的水平明显高于缺乏这些多态性的个体。我们的结论是，虽然IL-10或tnf - α表达的遗传变异与HCV清除率或ALT水平的改变无关，但tnf - α多态性可能与肝纤维化有关。(c) 2006 Elsevier Ltd.版权所有。
We investigated the effects of polymorphisms in interleukin (IL)-10 and tumor necrosis factor (TNF)-alpha on the natural course of hepatitis C virus (HCV) infection in a community-based population in Japan. A total of 460 anti-HCV antibody seropositive individuals were classified into two groups, those who were positive or negative for HCV RNA. In HCV RNA-positive individuals with at least four annual alanine amino transferase (ALT) measurements taken between 1993 and 2003, 74 exhibited persistently normal ALT levels, while 211 had one or more elevated ALT level tests. We examined the relationships between polymorphisms in the genes encoding IL-10 (-1082, -819, -592) or TNF-alpha (-308, -238) and HCV clearance, ALT abnormalities, or serum level of type IV collagen 7S, a marker of hepatic fibrosis. These polymorphisms were equally distributed among the patient subgroups with differential HCV RNA clearances or ALT abnormalities. Serum levels of type IV collagen 7S, however, were significantly higher in individuals with an A at position -238 or -308 in the TNF-alpha gene promoter than in individuals lacking these polymorphisms. We conclude that, while the relationships between inherited variations in IL-10 or TNF-alpha expression are not associated with alterations in HCV clearance or ALT levels, TNF-alpha polymorphisms may be associated with hepatic fibrosis. (c) 2006 Elsevier Ltd. All rights reserved.