Enantioselective synthesis of hydroxy ketones through cleavage and formation of acyloin linkage.: Enzymatic kinetic resolution via C-C bond cleavage
Enantioselective synthesis of hydroxy ketones through cleavage and formation of acyloin linkage.: Enzymatic kinetic resolution via C-C bond cleavage
复制标题
DOI：
10.1039/b100341k
复制
发表时间：
2001-01-01
期刊：
影响因子：
--
通讯作者：
Müller, M
中科院分区：
文献类型：
--
作者：
Demir, AS;Pohl, M;Müller, M
以芳香醛、外消旋安息香和脂肪醛为原料，通过酶催化的 C-C 键断裂和 C-C 键形成反应，以制备规模高产率获得了安息香和 (R)-2-羟基-1-苯基丙酮类似物的两种对映体。
Both enantiomers of benzoins and (R)-2-hydroxy-1-phenylpropanone analogues were obtained in high yield on a preparative scale starting from aromatic aldehydes, rac-benzoins and aliphatic aldehydes via enzyme-catalysed C-C bond cleavage and C-C bond formation reactions.