Melatonin influences sex-specific prenatal mortality in meadow voles.
Melatonin influences sex-specific prenatal mortality in meadow voles.
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褪黑激素影响草甸田鼠的性别特异性产前死亡率。
DOI：
10.1095/biolreprod51.5.873
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发表时间：
1994
影响因子：
3.6
通讯作者：
Dark,J
中科院分区：
文献类型：
--
作者：
Gorman,MR;Ferkin,MH;Dark,J
草原田鼠在产仔数、排卵率和产前死亡率方面表现出季节性变化。为了研究繁殖努力的季节性变化的近似基础，成年雌性田鼠，保持在长光周期（14小时光照/天），每天注射10微克褪黑激素2小时前光偏移，以延长夜间褪黑激素脉冲的持续时间。分娩时，对后代的数量、性别和体重进行评估。卵巢黄体（CL）的数量，潜在的产仔数的指数，用于计算产前存活率（即，幼仔/CL）。与生理盐水相比，在囊胚植入前（妊娠第1-6天）注射褪黑激素的母鼠的雌性而非雄性幼仔的产前存活率降低。在胚泡植入后（妊娠第7-21天）开始注射褪黑激素不影响产前存活率，也不影响植入前或植入后褪黑激素治疗对幼仔出生体重的影响。我们的结论是，性别特异性的产前存活是一个不稳定的功能田鼠繁殖，可能是在接近控制的光周期和褪黑激素前胚泡植入。
Meadow voles exhibit seasonal changes in litter size, ovulation rates, and prenatal mortality. To investigate the proximate bases of seasonal changes in reproductive effort, adult female voles, maintained in long photoperiods (14 h of light/day), were injected daily with 10 µg melatonin 2 h before light offset to extend the duration of the nighttime melatonin pulse. At parturition the number, sex, and weight of offspring were assessed. The number of ovarian corpora lutea (CL), an index of potential litter size, was used to calculate rates of prenatal survival (i.e., pups per CL). Prenatal survival rates were reduced in female but not male pups of dams that had been injected before blastocyst implantation (Days 1–6 of pregnancy) with melatonin as compared with saline. Melatonin injections initiated after blastocyst implantation (Days 7–21 of pregnancy) did not affect prenatal survival, nor were birth weights of pups affected by either pre- or postimplantation melatonin treatment. We conclude that sex-specific prenatal survival is a labile feature of vole reproduction that may be under proximate control of photoperiod and melatonin before blastocyst implantation.