Responsiveness of the quality of life in epilepsy inventory (QOLIE-89) in an antiepileptic drug trial
Responsiveness of the quality of life in epilepsy inventory (QOLIE-89) in an antiepileptic drug trial
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DOI：
10.1023/a:1022209105926
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发表时间：
2003-03-01
影响因子：
3.5
通讯作者：
Vickrey, BG
中科院分区：
文献类型：
--
作者：
Kim, S;Hays, RD;Vickrey, BG
本研究探讨了健康相关的生活质量（HRQOL）措施的反应性指数之间的关系管理的成年癫痫患者参加了抗癫痫药物试验。在基线和28周随访时完成癫痫生活质量（QOLIE）-89。六个反应性指标使用两个不同的临床显著性变化外部标准，计算16个QOLIE-89量表的每一个（效应量（ES）、标准化反应均值（SRM）、反应性统计量、配对t检验、受试者工作特征曲线下面积或ROC、F统计量）：（1）意识改变时无癫痫发作，（2）基线和随访时受试者总体状况自我评定的两类改善。16个QOLIE-89量表的6个反应性指数之间的斯皮尔曼相关性倾向于中等至大（斯皮尔曼rho = 0.53-1.00; 30个相关性中有29个p < 0.05）。两个外部变化标准的16个量表的反应性统计等级相似（斯皮尔曼rho = 0.62; p < 0.05），但其他反应性指数不同（均p > 0.05）。ES和SRM都很好地预测了其他指标，除了ROC，使用回归模型。总之，使用不同的反应性指数的结果是可比的给定的外部标准。然而，只有响应性统计数据在两个不同的外部标准中得出了可靠的结果。该HRQOL测量的响应性可以根据先前建立的ES基准来报告，ES基准可以从其他指数来预测。
This study examined relationships among responsiveness indices for health-related quality of life (HRQOL) measures administered to adults with epilepsy enrolled in an antiepileptic drug trial. The Quality of Life in Epilepsy (QOLIE)-89 was completed at baseline and at a 28-week follow-up. Six responsiveness indices (effect size (ES), standardized response mean (SRM), responsiveness statistic, paired t-test, area under receiver operating characteristic curve or ROC, F-statistic) were calculated for each of the 16 QOLIE-89 scales, using two different external criteria for clinically significant change: (1) attainment of freedom from seizures with altered awareness, and (2) a two-category improvement between baseline and follow-up in a self-rating of the subject's overall condition. Spearman correlations among the six responsiveness indices for the 16 QOLIE-89 scales tended to be moderate to large (Spearman's rho = 0.53-1.00; p's < 0.05 for 29 out of the 30 correlations). Rankings of the 16 scales across the two external criteria for change were similar for the responsiveness statistic (Spearman's rho = 0.62; p < 0.05), but dissimilar for the other responsiveness indices (all p > 0.05). Both ES and SRM were well predicted by the other indices, except for ROC, using regression modeling. In conclusion, results using different responsiveness indices are comparable for a given external criterion. However, only the responsiveness statistic yielded robust results across two different external criteria. Responsiveness of this HRQOL measure can be reported in terms of previously established benchmarks for ESs, which can be predicted from other indices.