Degenerative Lumbar Spine Disease: Estimating Global Incidence and Worldwide Volume
Degenerative Lumbar Spine Disease: Estimating Global Incidence and Worldwide Volume
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DOI：
10.1177/2192568218770769
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发表时间：
2018-12-01
影响因子：
2.4
通讯作者：
Shrime, Mark G.
中科院分区：
文献类型：
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作者：
Ravindra, Vijay M.;Senglaub, Steven S.;Shrime, Mark G.
研究设计：基于荟萃分析的计算。目的：腰椎退行性脊柱疾病（DSD）是一种常见的致残原因，但目前尚不存在可靠的全球负担测量方法。我们试图量化腰椎DSD的发病率，以确定世界卫生组织区域和世界银行收入群体中症状性腰椎DSD的全球总体负担。方法：我们使用一项荟萃分析来创建腰痛（LBP）患者中DSD病例的单一比例。将这些信息与LBP发病率结合起来，我们根据2015年全球疾病负担数据库计算了患有DSD和LBP的个体的全球发病率（即他们的DSD具有神经外科相关性）。结果：全球每年有2.66亿人（3.63%）患有DSD和LBP；估计发病率最高和最低的分别是欧洲（5.7%）和非洲（2.4%）。根据人口规模，低收入和中等收入国家的病例是高收入国家的4倍。全世界每年发现3900万人（0.53%）患有脊椎滑脱，4.03亿人（5.5%）患有症状性椎间盘退变，1.03亿人（1.41%）患有椎管狭窄。结论：全球每年共发现2.66亿人（3.63%）患有DSD和LBP。值得注意的是，高收入国家的数据质量更高，使得低收入和中等收入国家的总体量化不太完整。全球努力解决高需求地区腰椎退行性疾病对减少残疾很重要。
Study Design: Meta-analysis-based calculation.Objectives: Lumbar degenerative spine disease (DSD) is a common cause of disability, yet a reliable measure of its global burden does not exist. We sought to quantify the incidence of lumbar DSD to determine the overall worldwide burden of symptomatic lumbar DSD across World Health Organization regions and World Bank income groups.Methods: We used a meta-analysis to create a single proportion of cases of DSD in patients with low back pain (LBP). Using this information in conjunction with LBP incidence rates, we calculated the global incidence of individuals who have DSD and LBP (ie, their DSD has neurosurgical relevance) based on the Global Burden of Disease 2015 database.Results: We found that 266 million individuals (3.63%) worldwide have DSD and LBP each year; the highest and lowest estimated incidences were found in Europe (5.7%) and Africa (2.4%), respectively. Based on population sizes, low-and middle-income countries have 4 times as many cases as high-income countries. Thirty-nine million individuals (0.53%) worldwide were found to have spondylolisthesis, 403 million (5.5%) individuals worldwide with symptomatic disc degeneration, and 103 million (1.41%) individuals worldwide with spinal stenosis annually.Conclusions: A total of 266 million individuals (3.63%) worldwide were found to have DSD and LBP annually. Significantly, data quality is higher in high-income countries, making overall quantification in low-and middle-income countries less complete. A global effort to address degenerative conditions of the lumbar spine in regions with high demand is important to reduce disability.