Heterogeneities in schistosome transmission dynamics and control
Heterogeneities in schistosome transmission dynamics and control
复制标题
血吸虫传播动力学和控制的异质性
DOI：
10.1017/s003118209800331x
复制
发表时间：
1998
期刊：
影响因子：
2.4
通讯作者：
S. Chandiwana
中科院分区：
文献类型：
--
作者：
M. Woolhouse;J. Etard;Klaus Dietz;Patricia D. Ndhlovu;S. Chandiwana
我们回顾的理论框架，探索个人和空间异质性的影响模式的曝光和污染，并对基本的繁殖数，R 0，为人类染色体。对津巴布韦和马里5个社区的水接触数据的分析表明，影响是巨大的，R 0增加了6.5倍，主要是由于个人之间接触率的高度分散分布。出现了几个实际的结论：应避免将接触者集中在一个地点;如果不知道个人的接触者如何在各地点之间分布，就无法预测针对某些地点的控制的影响;针对对传播贡献最大的个人或地点的控制方案可能非常有效，但相反，如果遗漏了这些个人或地点中的任何一个，则将是无效的。
We review the theoretical framework for exploring the impact of individual and spatial heterogeneities in patterns of exposure and contamination and on the basic reproduction number, R0, for human schistosomes. Analysis of water contact data for 5 communities in Zimbabwe and Mali suggests that the impact is substantial, increasing R0 by factors of up to 6·5, mostly due to highly overdispersed distributions of contact rates among individuals. Several practical conclusions emerge: concentration of contacts at a single site should be avoided; the impact of control targeted at certain sites cannot be predicted without knowledge of how individuals' contacts are distributed among sites; control programmes targeted at individuals or sites contributing most to transmission can be very efficient but, conversely, will be ineffective if any of these individuals or sites are missed.