Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.
Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.
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DOI：
10.1038/ni.2353
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发表时间：
2012-06-24
影响因子：
30.5
通讯作者：
Amagai, Masayuki
中科院分区：
文献类型：
--
作者：
Nagao, Keisuke;Kobayashi, Tetsuro;Moro, Kazuyo;Ohyama, Manabu;Adachi, Takeya;Kitashima, Daniela Y.;Ueha, Satoshi;Horiuchi, Keisuke;Tanizaki, Hideaki;Kabashima, Kenji;Kubo, Akiharu;Cho, Young-hun;Clausen, Bjorn E.;Matsushima, Kouji;Suematsu, Makoto;Furtado, Glaucia C.;Lira, Sergio A.;Farber, Joshua M.;Udey, Mark C.;Amagai, Masayuki
朗格汉斯细胞（LC）是表皮树突状细胞，起源不完全清楚，与毛囊相关的原因不明。在这里，我们表明，在响应外部压力，小鼠毛囊招募Gr-1hi单核细胞衍生的前体LC的表皮进入依赖于趋化因子受体CCR 2和CCR 6，而趋化因子受体CCR 8抑制招聘的LC。不同的毛囊区域在CCR 2和CCR 6配体的表达上存在差异。峡部表达趋化因子CCL 2;漏斗部表达趋化因子CCL 20;而隆起部的角质形成细胞产生趋化因子CCL 8，其是CCR 8的配体。因此，不同的毛囊角质形成细胞亚群通过趋化因子产生的差异促进或抑制LC的再增殖，这也是人类的一个特征。前LC无法进入小鼠或人类的无毛皮肤，这使得毛囊成为LC的门户。
Langerhans cells (LCs) are epidermal dendritic cells with incompletely understood origins that associate with hair follicles for unknown reasons. Here we show that in response to external stress, mouse hair follicles recruited Gr-1hi monocyte-derived precursors of LCs whose epidermal entry was dependent on the chemokine receptors CCR2 and CCR6, whereas the chemokine receptor CCR8 inhibited the recruitment of LCs. Distinct hair-follicle regions had differences in their expression of ligands for CCR2 and CCR6. The isthmus expressed the chemokine CCL2; the infundibulum expressed the chemokine CCL20; and keratinocytes in the bulge produced the chemokine CCL8, which is the ligand for CCR8. Thus, distinct hair-follicle keratinocyte subpopulations promoted or inhibited repopulation with LCs via differences in chemokine production, a feature also noted in humans. Pre-LCs failed to enter hairless skin in mice or humans, which establishes hair follicles as portals for LCs.
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Langerhans细胞（LC）增殖介导了新生儿发育，体内平衡和与表皮LC网络的炎症相关扩张。
DOI：
10.1084/jem.20091586
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chorro L;Sarde A;Li M;Woollard KJ;Chambon P;Malissen B;Kissenpfennig A;Barbaroux JB;Groves R;Geissmann F
通讯作者：
Geissmann F
影响因子：
6.5
作者：
Kobayashi, Tetsuro;Iwasaki, Toshiroh;Ohyama, Manabu
通讯作者：
Ohyama, Manabu
DOI：
10.1084/jem.20071966
发表时间：
2007-12-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bursch LS;Wang L;Igyarto B;Kissenpfennig A;Malissen B;Kaplan DH;Hogquist KA
通讯作者：
Hogquist KA
影响因子：
10.3
作者：
Ghoreishi, M.;Martinka, M.;Dutz, J. P.
通讯作者：
Dutz, J. P.
影响因子：
3
作者：
Clausen, BE;Burkhardt, C;Förster, I
通讯作者：
Förster, I