Effect of immune modulation on TT virus (TTV) and TTV-Like-Mini-Virus (TLMV) viremia
Effect of immune modulation on TT virus (TTV) and TTV-Like-Mini-Virus (TLMV) viremia
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DOI：
10.1002/jmv.10356
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发表时间：
2003-05-01
影响因子：
12.7
通讯作者：
Grinde, B
中科院分区：
文献类型：
--
作者：
Moen, EM;Sagedal, S;Grinde, B
本研究旨在探讨两种慢性复制病毒TT病毒（TTV）和TTV样微小病毒（TI-MV）与宿主防御系统的相互作用。来自三组受试者的连续血清样品，经历了他们的抗病毒防御的修改，通过实时PCR测试以测量病毒滴度的变化，并通过序列分析来指示病毒血症的增加是否可归因于不熟悉的菌株的感染：1）在肾移植后接受免疫抑制剂的患者中，病毒滴度倾向于增加; 2）在接受已知会引起免疫抑制的极端训练的士兵中，观察到滴度的不显著增加;和3）对患有丙型肝炎病毒的患者进行干扰素治疗导致TTV和TLMV滴度暂时降低。病毒血症的增加只是偶尔与新菌株的出现有关。上述结果增加了关于这些病毒如何受宿主影响的知识。(C)2003 Wiley-Liss，Inc.
The present study was designed to investigate how two chronically replicating viruses, TT virus (TTV) and TTV-Iike mini virus (TI-MV), interact with host defence systems. Successive serum samples from three groups of subjects, undergoing modifications of their antiviral defence, were tested by real-time PCR to measure changes in viral titers, and by sequence analyses to indicate whether increases in viremia could be attributed to infection with an unfamiliar strain: 1) in patients receiving immunosuppressants subsequent to kidney transplantation, viral titers tended to increase; 2) in soldiers undergoing extreme training known to cause immunosuppression, insignificant increases in titers were observed; and 3) interferon treatment of patients with hepatitis C virus caused a temporary decrease in TTV and TLMV titers. Increases in viremia were associated only occasionally with the appearance of novel strains. The above results add to knowledge on how these viruses are influenced by the host. (C) 2003 Wiley-Liss, Inc.