Effect of renal ischemia on urinary excretion of lithium in rats
Effect of renal ischemia on urinary excretion of lithium in rats
复制标题
肾缺血对大鼠尿锂排泄的影响
DOI：
10.1002/bdd.2163
复制
发表时间：
2018
影响因子：
2.1
通讯作者：
Nabekura T
中科院分区：
文献类型：
--
作者：
Uwai Y;Suzuki T;Kondo R;Kawasaki T;Nabekura T
双相情感障碍患者服用的锂主要经尿液排泄，并涉及肾小管重吸收。本研究的特点是肾缺血60分钟或90分钟的大鼠肾排泄锂。静脉注射氯化锂25 mg/kg后，测定锂的药代动力学参数。在假手术大鼠中，锂的肾脏清除率计算为1.49 ml/min/kg，其与肌酐清除率（排泄分数）的比值为43.4%。肾缺血抑制锂的肾脏排泄，但不影响其排泄分数。肾缺血90 min大鼠尿pH值明显高于其他各组，与肾缺血大鼠锂排泄分数线性回归显示中度相关（r = 0.650，p = 0.00193）。本研究证实了肾缺血对大鼠肾脏排锂的影响。提示肾缺血不仅损害肾小球滤过功能，而且损害锂的重吸收。
Lithium, administered to patients with bipolar disorders, is mainly excreted in the urine, and tubular reabsorption is involved. This study characterized the renal excretion of lithium in rats subjected to renal ischemia for 60 min or 90 min. After intravenous injection of lithium chloride at 25 mg/kg, the pharmacokinetic parameters of lithium were determined. In sham‐operated rats, the renal clearance of lithium was calculated to be 1.49 ml/min/kg, and its ratio to creatinine clearance (fractional excretion) was 43.4%. Renal ischemia inhibited the renal excretion of lithium, and did not affect its fractional excretion. The urinary pH of rats with renal ischemia for 90 min was significantly higher than those of the other groups, and the linear regression with the fractional excretion of lithium in rats with renal ischemia showed a moderate correlation (r = 0.650, p = 0.00193). This study demonstrated the effect of renal ischemia on the renal excretion of lithium in rats. It was suggested that not only glomerular filtration but also the reabsorption of lithium was impaired by renal ischemia.